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Table 1.

Transepithelial resistance (TER) in polarized control and HB-EGF mutant transfected cells with and without Batimastat (BB-94)

	Batimastat (BB-94)	Day 1	Day 2	Day 3	Day 4	Day 5
MDCK^con	-	13.33±1.56	49.50±2.813	107.50±3.04	130.16±2.93	85.83±3.53
	+	13.66±1.41	60.66±2.60	107.16±3.31	134.83±3.72	97.83±4.93
MDCK^5aa	-	13.16±1.58	60.16±3.00	310.50±3.99^**	436.66±4.93^**	306.66±4.90^**
	+	15.00±1.77	63.50±2.83	332.16±7.91^**	447.16±3.895^**	318.33±4.19^**
MDCK^pro	-	13.50±1.73	48.33±2.49	122.83±3.50	215.16±4.88^*	512.33±6.70^**
	+	11.66±1.12	76.83±3.44	357.00±4.56^**	538.66±4.66^**	401.16±6.24^**
MDCK^sol	-	12.00±1.064	30.83±2.59	39.66±2.06	35.16±2.65	48.16±2.44
	+	12.16±1.05	39.00±2.017	47.66±2.42	48.50±3.11	54.33±1.96

	Batimastat (BB-94)	Day 1	Day 2	Day 3	Day 4	Day 5
MDCK^con	-	13.33±1.56	49.50±2.813	107.50±3.04	130.16±2.93	85.83±3.53
	+	13.66±1.41	60.66±2.60	107.16±3.31	134.83±3.72	97.83±4.93
MDCK^5aa	-	13.16±1.58	60.16±3.00	310.50±3.99^**	436.66±4.93^**	306.66±4.90^**
	+	15.00±1.77	63.50±2.83	332.16±7.91^**	447.16±3.895^**	318.33±4.19^**
MDCK^pro	-	13.50±1.73	48.33±2.49	122.83±3.50	215.16±4.88^*	512.33±6.70^**
	+	11.66±1.12	76.83±3.44	357.00±4.56^**	538.66±4.66^**	401.16±6.24^**
MDCK^sol	-	12.00±1.064	30.83±2.59	39.66±2.06	35.16±2.65	48.16±2.44
	+	12.16±1.05	39.00±2.017	47.66±2.42	48.50±3.11	54.33±1.96

Values represent TER±s.e.m.; ^*P<0.01; ^**P<0.001. The data are representative of the data obtained from two independent clones for each transfected mutant molecule from three independent experiments.

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