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Table 1.

Transepithelial resistance (TER) in polarized control and HB-EGF mutant transfected cells with and without Batimastat (BB-94)

Batimastat (BB-94) Day 1 Day 2 Day 3 Day 4 Day 5
MDCKcon  -   13.33±1.56   49.50±2.813   107.50±3.04   130.16±2.93   85.83±3.53  
  +   13.66±1.41   60.66±2.60   107.16±3.31   134.83±3.72   97.83±4.93  
MDCK5aa  -   13.16±1.58   60.16±3.00   310.50±3.99**  436.66±4.93**  306.66±4.90** 
  +   15.00±1.77   63.50±2.83   332.16±7.91**  447.16±3.895**  318.33±4.19** 
MDCKpro  -   13.50±1.73   48.33±2.49   122.83±3.50   215.16±4.88*  512.33±6.70** 
  +   11.66±1.12   76.83±3.44   357.00±4.56**  538.66±4.66**  401.16±6.24** 
MDCKsol  -   12.00±1.064   30.83±2.59   39.66±2.06   35.16±2.65   48.16±2.44  
  +   12.16±1.05   39.00±2.017   47.66±2.42   48.50±3.11   54.33±1.96  
Batimastat (BB-94) Day 1 Day 2 Day 3 Day 4 Day 5
MDCKcon  -   13.33±1.56   49.50±2.813   107.50±3.04   130.16±2.93   85.83±3.53  
  +   13.66±1.41   60.66±2.60   107.16±3.31   134.83±3.72   97.83±4.93  
MDCK5aa  -   13.16±1.58   60.16±3.00   310.50±3.99**  436.66±4.93**  306.66±4.90** 
  +   15.00±1.77   63.50±2.83   332.16±7.91**  447.16±3.895**  318.33±4.19** 
MDCKpro  -   13.50±1.73   48.33±2.49   122.83±3.50   215.16±4.88*  512.33±6.70** 
  +   11.66±1.12   76.83±3.44   357.00±4.56**  538.66±4.66**  401.16±6.24** 
MDCKsol  -   12.00±1.064   30.83±2.59   39.66±2.06   35.16±2.65   48.16±2.44  
  +   12.16±1.05   39.00±2.017   47.66±2.42   48.50±3.11   54.33±1.96  

Values represent TER±s.e.m.; *P<0.01; **P<0.001. The data are representative of the data obtained from two independent clones for each transfected mutant molecule from three independent experiments.

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