The Company of Biologists

Table 1.

PcG protein complexes regulate a plethora of cellular processes

Cellular function	Species or cell system	PcG proteins or protein complexes implicated^{^*}	References^{^†}
Actin polymerization	Human and mouse T cells	EZH2	Su et al., 2005
Cancer development, stem cell plasticity and cell fate determination	Human, mouse, Drosophila	PRC1, PRC2 (in particular BMI1, EZH2)	Reviewed by Rajasekhar and Begemann, 2007; Sparmann and van Lohuizen, 2006
Cell cycle control	Human, mouse, Drosophila	PRC1, PRC2	Reviewed by Martinez and Cavalli, 2006
Genomic imprinting	Mouse	EED, EZH2, RNF2	Mager et al., 2003; Pandey et al., 2008; Puschendorf et al., 2008; Terranova et al., 2008
Mitochondrial function and redox homeostasis	Mouse	BMI1	Liu et al., 2009
Senescence	Human and mouse fibroblasts	PRC1, PRC2 (in particular BMI1, EZH2)	Bracken et al., 2007; Dietrich et al., 2007; reviewed by Guney et al., 2006
Spermatogenesis	Drosophila	Pc	Chen et al., 2005
X-chromosome inactivation	Mouse	PRC1, PRC2	Reviewed by Heard, 2005; Lee, 2009

Cellular function	Species or cell system	PcG proteins or protein complexes implicated^{^*}	References^{^†}
Actin polymerization	Human and mouse T cells	EZH2	Su et al., 2005
Cancer development, stem cell plasticity and cell fate determination	Human, mouse, Drosophila	PRC1, PRC2 (in particular BMI1, EZH2)	Reviewed by Rajasekhar and Begemann, 2007; Sparmann and van Lohuizen, 2006
Cell cycle control	Human, mouse, Drosophila	PRC1, PRC2	Reviewed by Martinez and Cavalli, 2006
Genomic imprinting	Mouse	EED, EZH2, RNF2	Mager et al., 2003; Pandey et al., 2008; Puschendorf et al., 2008; Terranova et al., 2008
Mitochondrial function and redox homeostasis	Mouse	BMI1	Liu et al., 2009
Senescence	Human and mouse fibroblasts	PRC1, PRC2 (in particular BMI1, EZH2)	Bracken et al., 2007; Dietrich et al., 2007; reviewed by Guney et al., 2006
Spermatogenesis	Drosophila	Pc	Chen et al., 2005
X-chromosome inactivation	Mouse	PRC1, PRC2	Reviewed by Heard, 2005; Lee, 2009

`PRC1, PRC2' indicates that multiple PcG members have been shown to be involved in a specific cellular function.

Owing to space limitations, only selected references or reviews are cited.