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Table 1.

PcG protein complexes regulate a plethora of cellular processes

Cellular functionSpecies or cell systemPcG proteins or protein complexes implicated*References
Actin polymerization Human and mouse T cells EZH2 Su et al., 2005 
Cancer development, stem cell plasticity and cell fate determination Human, mouse, Drosophila PRC1, PRC2 (in particular BMI1, EZH2) Reviewed by Rajasekhar and Begemann, 2007; Sparmann and van Lohuizen, 2006 
Cell cycle control Human, mouse, Drosophila PRC1, PRC2 Reviewed by Martinez and Cavalli, 2006 
Genomic imprinting Mouse EED, EZH2, RNF2 Mager et al., 2003; Pandey et al., 2008; Puschendorf et al., 2008; Terranova et al., 2008 
Mitochondrial function and redox homeostasis Mouse BMI1 Liu et al., 2009 
Senescence Human and mouse fibroblasts PRC1, PRC2 (in particular BMI1, EZH2) Bracken et al., 2007; Dietrich et al., 2007; reviewed by Guney et al., 2006 
Spermatogenesis Drosophila Pc Chen et al., 2005 
X-chromosome inactivation Mouse PRC1, PRC2 Reviewed by Heard, 2005; Lee, 2009 
Cellular functionSpecies or cell systemPcG proteins or protein complexes implicated*References
Actin polymerization Human and mouse T cells EZH2 Su et al., 2005 
Cancer development, stem cell plasticity and cell fate determination Human, mouse, Drosophila PRC1, PRC2 (in particular BMI1, EZH2) Reviewed by Rajasekhar and Begemann, 2007; Sparmann and van Lohuizen, 2006 
Cell cycle control Human, mouse, Drosophila PRC1, PRC2 Reviewed by Martinez and Cavalli, 2006 
Genomic imprinting Mouse EED, EZH2, RNF2 Mager et al., 2003; Pandey et al., 2008; Puschendorf et al., 2008; Terranova et al., 2008 
Mitochondrial function and redox homeostasis Mouse BMI1 Liu et al., 2009 
Senescence Human and mouse fibroblasts PRC1, PRC2 (in particular BMI1, EZH2) Bracken et al., 2007; Dietrich et al., 2007; reviewed by Guney et al., 2006 
Spermatogenesis Drosophila Pc Chen et al., 2005 
X-chromosome inactivation Mouse PRC1, PRC2 Reviewed by Heard, 2005; Lee, 2009 
*

`PRC1, PRC2' indicates that multiple PcG members have been shown to be involved in a specific cellular function.

Owing to space limitations, only selected references or reviews are cited.

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