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Table 4.

Ventilatory variables during heliox trials for 48 female mice from lines selected for high wheel-running performance or bred randomly as controls

SelectedControlPselectionPlinesPbody massP(O2max)
Breathing frequency (Hz) 6.861±0.147 6.306±0.147 0.052 0.294 0.690 0.518 
Breathing frequency(Hz)a 6.878±0.143 6.289±0.143 0.037 0.308 0.375  
Breathing frequency(Hz)b 6.823±0.130 6.345±0.130 0.041 0.276   
Tidal volume (ml) 0.270±0.008 0.274±0.008 0.775 0.017 0.890 
Minute volume (ml min-1111.4±3.8 103.7±3.8 0.253 0.026 0.828 
O2 extraction (%) 31.24±1.22 32.39±1.22 0.580 0.068 0.0064 
SelectedControlPselectionPlinesPbody massP(O2max)
Breathing frequency (Hz) 6.861±0.147 6.306±0.147 0.052 0.294 0.690 0.518 
Breathing frequency(Hz)a 6.878±0.143 6.289±0.143 0.037 0.308 0.375  
Breathing frequency(Hz)b 6.823±0.130 6.345±0.130 0.041 0.276   
Tidal volume (ml) 0.270±0.008 0.274±0.008 0.775 0.017 0.890 
Minute volume (ml min-1111.4±3.8 103.7±3.8 0.253 0.026 0.828 
O2 extraction (%) 31.24±1.22 32.39±1.22 0.580 0.068 0.0064 

S, selected; C, controls.

Significance of the effects of selection history, line, and body mass are from nested analysis of covariance (ANCOVA), including age as a covariate.

Adjusted means and s.e.m. were calculated from SAS PROC MIXED for a female of 25.0 g and 71 days of age. Values are means ± s.e.m.; values in bold indicate statistically significant effects(P≤0.05).

a

O2max not included in the model

b

O2max and body mass not included in the model

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