Skip to Main Content
Table 3.

Metabolic and locomotor variables for 48 female mice from lines selected for high wheel-running performance or bred randomly as controls

SelectedControlS/CPselectionPlinesPbody mass
O2max,W(mlO2 min-14.465±0.088 3.710±0.086 1.20 0.002 <0.001 
O2max,T(mlO2 min-15.434±0.170 5.096±0.170 1.07 0.238 0.083 <0.001 
O2max,H(mlO2 min-17.149±0.180 6.747±0.180 1.06 0.189 0.123 <0.001 
O2max,T(mlO2 g-1min-1)a 0.222±0.006 0.207±0.006 1.07 0.175 0.332 0.017 
O2max,H(mlO2 g-1min-1)a 0.289±0.007 0.272±0.007 1.06 0.160 0.286 0.001 
RMR5,W (mlO2 min-10.845±0.026 0.836±0.026 1.01 0.831 0.653 <0.001 
ScopeW 5.349±0.123 4.33±0.120 1.23 0.001  
ScopeT 6.556±0.250 5.985±0.250 1.10 0.157 0.243  
ScopeH 8.656±0.222 7.883±0.222 1.10 0.049  
SpeedMax,W (m min-135.395±1.783 21.896±1.753 1.62 0.002 0.674  
SpeedMax,T (m min-137.848±1.855 33.210±1.855 1.14 0.128 0.515  
SelectedControlS/CPselectionPlinesPbody mass
O2max,W(mlO2 min-14.465±0.088 3.710±0.086 1.20 0.002 <0.001 
O2max,T(mlO2 min-15.434±0.170 5.096±0.170 1.07 0.238 0.083 <0.001 
O2max,H(mlO2 min-17.149±0.180 6.747±0.180 1.06 0.189 0.123 <0.001 
O2max,T(mlO2 g-1min-1)a 0.222±0.006 0.207±0.006 1.07 0.175 0.332 0.017 
O2max,H(mlO2 g-1min-1)a 0.289±0.007 0.272±0.007 1.06 0.160 0.286 0.001 
RMR5,W (mlO2 min-10.845±0.026 0.836±0.026 1.01 0.831 0.653 <0.001 
ScopeW 5.349±0.123 4.33±0.120 1.23 0.001  
ScopeT 6.556±0.250 5.985±0.250 1.10 0.157 0.243  
ScopeH 8.656±0.222 7.883±0.222 1.10 0.049  
SpeedMax,W (m min-135.395±1.783 21.896±1.753 1.62 0.002 0.674  
SpeedMax,T (m min-137.848±1.855 33.210±1.855 1.14 0.128 0.515  

S, selected; C, controls.

Significance of the effects of selection history (S vs C),replicate line within line type, and body mass are from nested analysis of covariance (ANCOVA), including age as a covariate. Adjusted means were calculated from SAS PROC MIXED for a female of 25.3±0.2 g (mass indices were not the same for all traits, because measurements were performed on separate days) and 72 days of age (for scope and speed, mass was not included in the model; see Statistical analyses).

W, wheel (voluntary exercise); T, treadmill (forced exercise); H,heliox.

Values are adjusted means ± s.e.m.; values in bold indicate significant effects (P≤0.05).

RMR5,W (lowest 5 min O2 average during wheel trials); Scope, aerobic scope(=O2max/RMR).

a

Mass-specific metabolic rates

Close Modal

or Create an Account

Close Modal
Close Modal