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Table 2.

Birthdate affects the sensory modalities of the trigeminal sensory ganglia

Day 1Day 2Day 3Day 4Day 5Day 6Day 7Day 8
Response to touch
 

 

 

 

 

 

 

 

 
Wild type 100±0% 100±0% 100±0% 100±0% 100±0% 100±0% 100±0% 100±0% 
Anti-proliferation treatment 100±0% 100±0% 100±0% n/d n/d n/d n/d n/d 
neurogenin1 (morpholino) 0±0% 15.00±11% 65.00±31.52% 51.67±28.95% 81.82±23.24% 100±0% 100±0% 100±0% 
neurogenin1 (mutant)
 
0±0%
 
3.33±2.25%
 
41.67±9.36%
 
66.67±6.67%
 
76.67±7.72%
 
100±0%
 
100±0%
 
100±0%
 
Response to mustard oil
 

 

 

 

 

 

 

 

 
Wild type 100±0% 100±0% 100±0% 100±0% 100±0% 100±0% 100±0% 100±0% 
Anti-proliferation treatment 100±0% 100±0% 100±0% n/d n/d n/d n/d n/d 
neurogenin1 (morpholino) 0±0% 0±0% 0±0% 0±0% 0±0% 0±0% 0±0% 0±0% 
neurogenin1 (mutant) 0±0% 0±0% 0±0% 0±0% 0±0% 0±0% 0±0% 0±0% 
Day 1Day 2Day 3Day 4Day 5Day 6Day 7Day 8
Response to touch
 

 

 

 

 

 

 

 

 
Wild type 100±0% 100±0% 100±0% 100±0% 100±0% 100±0% 100±0% 100±0% 
Anti-proliferation treatment 100±0% 100±0% 100±0% n/d n/d n/d n/d n/d 
neurogenin1 (morpholino) 0±0% 15.00±11% 65.00±31.52% 51.67±28.95% 81.82±23.24% 100±0% 100±0% 100±0% 
neurogenin1 (mutant)
 
0±0%
 
3.33±2.25%
 
41.67±9.36%
 
66.67±6.67%
 
76.67±7.72%
 
100±0%
 
100±0%
 
100±0%
 
Response to mustard oil
 

 

 

 

 

 

 

 

 
Wild type 100±0% 100±0% 100±0% 100±0% 100±0% 100±0% 100±0% 100±0% 
Anti-proliferation treatment 100±0% 100±0% 100±0% n/d n/d n/d n/d n/d 
neurogenin1 (morpholino) 0±0% 0±0% 0±0% 0±0% 0±0% 0±0% 0±0% 0±0% 
neurogenin1 (mutant) 0±0% 0±0% 0±0% 0±0% 0±0% 0±0% 0±0% 0±0% 

Wild-type, neurogenin1 morphant and neurogenin1 mutant zebrafish were tested for their response to touch and allyl isothiocyanate starting at 24 hpf (day 1) until 192 hpf (day 8). Touch stimuli were delivered by touching the head of the zebrafish with a glass needle. A solution of 1%allyl isothiocyanate was applied onto the head. Larvae were considered responsive if they instantaneously swam away from the source of the stimulus. On each day of development, individual zebrafish were tested five times and responsiveness was assessed as the percentage of time the animal reacted to the stimulus. The s.e. is indicated below each percentage (n=12). Wild-type and neurogenin1-depleted 96 hpf larvae were responsive to touch, but only wild-type larvae were responsive to allyl isothiocyanate.

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