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Table 1.

Conserved X-box sequences in nph-1 and nph-4 homologs

Species Gene Location* X-box sequence
C. elegans nph-1(M28.7)   −77 to −63  GTTGCC AGG  GGCAAC 
C. briggsae nph-1(CBG03043)   −68 to −55  GTTGCC AT GGTCAC 
Mouse  nephrocystin-1  −14 to −1  GTTTCC  CT GACAAC 
C. elegans nph-1(R13h4.1)   −168 to −155   ATTTCC AT GACAAC 
C. briggsae nph-4(CBG23249)   −186 to −173   ATTTCC AT GGCAAC 
Mouse   nephrocystin-4   −231 to −218  GTCTCC  TA  GGTAAC 
Consensus X-box (C. elegans)    GTHNYY AT RRNAAC 
Species Gene Location* X-box sequence
C. elegans nph-1(M28.7)   −77 to −63  GTTGCC AGG  GGCAAC 
C. briggsae nph-1(CBG03043)   −68 to −55  GTTGCC AT GGTCAC 
Mouse  nephrocystin-1  −14 to −1  GTTTCC  CT GACAAC 
C. elegans nph-1(R13h4.1)   −168 to −155   ATTTCC AT GACAAC 
C. briggsae nph-4(CBG23249)   −186 to −173   ATTTCC AT GGCAAC 
Mouse   nephrocystin-4   −231 to −218  GTCTCC  TA  GGTAAC 
Consensus X-box (C. elegans)    GTHNYY AT RRNAAC 
*

For C. elegans and C. briggsae these positions are relative to the translational start site. The mouse positions are relative to the start of transcription.

R=G/A; Y=C/T; H=A/T.C; N=G/A/T/C; bold letters denote a match to the C. elegans X-box consensus sequence.

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