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Table 1.

Summary of phenotypes caused by interfering with Cxcl12/Cxcr4 signaling




Olfactory placode assembly*

Olfactory axon projection (% OE with no axon projection)
Wild type Normal Normal (0%, n=264) 
odylNormal Normal (0%, n=162) 
odylody Disorganized Impaired (41%, n=68) 
cxcr4b MO Disorganized Impaired (3%, n=62) 
cxcl12a MO Disorganized Impaired (4%, n=76) 
cxcl12b MO Normal Normal (0%, n=134) 
Ubiquitous Cxcl12a (HS at 12 hpf) Disorganized Normal 
Ubiquitous Cxcl12a (HS at 19 hpf)
 
Normal
 
Normal
 



Olfactory placode assembly*

Olfactory axon projection (% OE with no axon projection)
Wild type Normal Normal (0%, n=264) 
odylNormal Normal (0%, n=162) 
odylody Disorganized Impaired (41%, n=68) 
cxcr4b MO Disorganized Impaired (3%, n=62) 
cxcl12a MO Disorganized Impaired (4%, n=76) 
cxcl12b MO Normal Normal (0%, n=134) 
Ubiquitous Cxcl12a (HS at 12 hpf) Disorganized Normal 
Ubiquitous Cxcl12a (HS at 19 hpf)
 
Normal
 
Normal
 

All embryos carry the omp:yfp transgene and the phenotypes are assessed by observing YFP-labeled cell bodies and axons at 1 dpf and 3 dpf,respectively.

*

For details, see Fig. 4.

Embryos obtained by crossing hsp:cxcl12a/+ adults with wild-type adults exhibit normal axon projection after heat shock (HS) at either 12 hpf(n=113 embryos) or 19 hpf (n=145 embryos).

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