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Table 2.

Genes differentially expressed in human skin fibroblasts in UVB-induced SIPS

Gene Name UVB/CTL Function GenBank
IGF-BP3   insulin growth factor binding protein 3   ↑ 2,7   growth factor   X64875  
HSP70   heat shock 70 kD protein 1   ↑ 2,5   defense system   AB023420  
HMOX   heme-oxygenase   ↑ 2,4   defense system   NM_002133  
IL-1B   interleukin 1 beta   ↑ 2,4   cytokine   M15330  
OSTE   osteonectin   ↑ 2,4   extracellular matrix   NM_003118  
ODC   ornithine decarboxylase 1   ↑ 2,3   cell cycle   NM_002539  
HSP90A   heat shock 90 kD protein 1 alpha   ↑ 2,3   defense system   X15183  
COL1A1   collagen 1 alpha-1   ↑ 2,2   extracellular matrix   NM_000088  
MAX   MAX protein   ↑ 2,2   cell cycle   NM_002382  
CTGF   connective tissue growth factor   ↑ 2,1   cell cycle   U14750  
PCNA   proliferating cell nuclear antigen   ↑ 2,1   control of DNA replication   NM002592  
TPA   plasminogen activator tissue   ↑ 2,1   extracellular matrix   NM_000930  
CCND-1   cyclin D1   ↑ 2,1   cell cycle   NM_053056  
MMP-1   matrix metalloproteinase 1   ↑ 2,1   degradation of extracellular matrix   NM_002421  
MT2A   metallothionein 2A   ↑ 2   defense system   V00594  
APO J   apolipoprotein J   ↑ 2   defense system   J02908  
COL3A1   collagen 3 alpha-1   ↑ 2   extracellular matrix   NM_000090  
HSP40   heat shock 40 kD protein 1   ↑ 2   defense system   D49547  
MEK-1   mitogen activated protein kinase kinase 1   ↑ 2   cell cycle   L11284  
p21   cyclin dependent kinase inhibitor 1A   ↑ 1,9   cell cycle   U03106  
NRG-1   neuregulin   ↑ 1,9   cell cycle   M94165  
FN1   fibronectin   ↑ 1,9   extracellular matrix   X02761  
TGFβRII   transforming growth factor-beta receptor II   ↑ 1,9   growth factor   D50685  
Il-11   interleukin 11   ↑ 1,8   cytokine   NM_000641  
MMP-2   matrix metalloproteinase 2   ↑ 1,8   degradation of extracellular matrix   NM_004530  
ANX-1   annexin 1   ↑ 1,8   anti-inflammatory   NM_000700  
HSP70B   heat shock 70 kD protein 6   ↑ 1,8   defense system   NM_002155  
IGF-BP5   insulin growth factor binding protein 5   ↑ 1,8   growth factor   M65062  
JNK-2   mitogen activated protein kinase 9   ↑ 1,8   defense system   U09759  
CANX   calnexin   ↑ 1,8   cell cycle   NM_001746  
HSP27   heat shock 27 kD protein 1   ↑ 1,8   defense system   AB020027  
EF1A   eucaryotic translation elongation factor-alpha   ↑ 1,7   protein synthesis   AY043301  
PRX VI   peroxiredoxin VI   ↑ 1,7   defense system   NM_004905  
MDM2   MDM2   ↑ 1,7   cell cycle   NM_002392  
GPX   glutathion peroxidase   ↑ 1,6   defense system   M21304  
H2BS   histone 2B member B/S consensus   ↑ 1,6   cell cycle   NM_080593  
CCNH   cyclin H   ↑ 1,6   cell cycle   NM_001239  
FMOD   fibromodulin   ↓ 0,6   extracellular matrix   NM_002023  
ICAM-1   intracellular adhesion molecule 1   ↓ 0,3   extracellular matrix   J031032  
Gene Name UVB/CTL Function GenBank
IGF-BP3   insulin growth factor binding protein 3   ↑ 2,7   growth factor   X64875  
HSP70   heat shock 70 kD protein 1   ↑ 2,5   defense system   AB023420  
HMOX   heme-oxygenase   ↑ 2,4   defense system   NM_002133  
IL-1B   interleukin 1 beta   ↑ 2,4   cytokine   M15330  
OSTE   osteonectin   ↑ 2,4   extracellular matrix   NM_003118  
ODC   ornithine decarboxylase 1   ↑ 2,3   cell cycle   NM_002539  
HSP90A   heat shock 90 kD protein 1 alpha   ↑ 2,3   defense system   X15183  
COL1A1   collagen 1 alpha-1   ↑ 2,2   extracellular matrix   NM_000088  
MAX   MAX protein   ↑ 2,2   cell cycle   NM_002382  
CTGF   connective tissue growth factor   ↑ 2,1   cell cycle   U14750  
PCNA   proliferating cell nuclear antigen   ↑ 2,1   control of DNA replication   NM002592  
TPA   plasminogen activator tissue   ↑ 2,1   extracellular matrix   NM_000930  
CCND-1   cyclin D1   ↑ 2,1   cell cycle   NM_053056  
MMP-1   matrix metalloproteinase 1   ↑ 2,1   degradation of extracellular matrix   NM_002421  
MT2A   metallothionein 2A   ↑ 2   defense system   V00594  
APO J   apolipoprotein J   ↑ 2   defense system   J02908  
COL3A1   collagen 3 alpha-1   ↑ 2   extracellular matrix   NM_000090  
HSP40   heat shock 40 kD protein 1   ↑ 2   defense system   D49547  
MEK-1   mitogen activated protein kinase kinase 1   ↑ 2   cell cycle   L11284  
p21   cyclin dependent kinase inhibitor 1A   ↑ 1,9   cell cycle   U03106  
NRG-1   neuregulin   ↑ 1,9   cell cycle   M94165  
FN1   fibronectin   ↑ 1,9   extracellular matrix   X02761  
TGFβRII   transforming growth factor-beta receptor II   ↑ 1,9   growth factor   D50685  
Il-11   interleukin 11   ↑ 1,8   cytokine   NM_000641  
MMP-2   matrix metalloproteinase 2   ↑ 1,8   degradation of extracellular matrix   NM_004530  
ANX-1   annexin 1   ↑ 1,8   anti-inflammatory   NM_000700  
HSP70B   heat shock 70 kD protein 6   ↑ 1,8   defense system   NM_002155  
IGF-BP5   insulin growth factor binding protein 5   ↑ 1,8   growth factor   M65062  
JNK-2   mitogen activated protein kinase 9   ↑ 1,8   defense system   U09759  
CANX   calnexin   ↑ 1,8   cell cycle   NM_001746  
HSP27   heat shock 27 kD protein 1   ↑ 1,8   defense system   AB020027  
EF1A   eucaryotic translation elongation factor-alpha   ↑ 1,7   protein synthesis   AY043301  
PRX VI   peroxiredoxin VI   ↑ 1,7   defense system   NM_004905  
MDM2   MDM2   ↑ 1,7   cell cycle   NM_002392  
GPX   glutathion peroxidase   ↑ 1,6   defense system   M21304  
H2BS   histone 2B member B/S consensus   ↑ 1,6   cell cycle   NM_080593  
CCNH   cyclin H   ↑ 1,6   cell cycle   NM_001239  
FMOD   fibromodulin   ↓ 0,6   extracellular matrix   NM_002023  
ICAM-1   intracellular adhesion molecule 1   ↓ 0,3   extracellular matrix   J031032  

Total mRNA was collected at 72 hours after a series of 10 UVB stresses at 250 mJ/cm2.

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