Table 1.

MLC phosphorylation-associated barrier regulation in intestinal epithelia

Increased MLC phosphorylation Reduced resistance Size selectivity Reference
tMLCK expression (cultured monolayers)   150%   18%   mannitol ≫ inulin   
Na+-nutrient cotransport (cultured monolayers)   208%   22%   mannitol ≫ inulin  Turner et al., 1997  
Na+-nutrient cotransport (isolated mucosae)   145%   22%   mannitol ≫ inulin  Berglund et al., 2001; Fihn et al., 2000  
Increased MLC phosphorylation Reduced resistance Size selectivity Reference
tMLCK expression (cultured monolayers)   150%   18%   mannitol ≫ inulin   
Na+-nutrient cotransport (cultured monolayers)   208%   22%   mannitol ≫ inulin  Turner et al., 1997  
Na+-nutrient cotransport (isolated mucosae)   145%   22%   mannitol ≫ inulin  Berglund et al., 2001; Fihn et al., 2000  
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