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Table 1.

Fate of cardiomyocytes transplanted into regenerating limb stumps or intact limbs

Labeled, implanted cells (in %) after
1 day 15 days 30 days
Transplantation into the non-injured limb (control)     
    Apoptosis   6±1   1±1   0±0  
Transplantation into regenerating limb stump     
    Apoptosis   3.5±1.5   0±0   0±0  
    Loss of cardiomyocyte markers   96.5±1.5   100±0   100±0  
    Presence of blastemal markers   35±5   0±0   0±0  
    Expression of skeletal muscle markers   0±0   40±5   65±5  
Labeled, implanted cells (in %) after
1 day 15 days 30 days
Transplantation into the non-injured limb (control)     
    Apoptosis   6±1   1±1   0±0  
Transplantation into regenerating limb stump     
    Apoptosis   3.5±1.5   0±0   0±0  
    Loss of cardiomyocyte markers   96.5±1.5   100±0   100±0  
    Presence of blastemal markers   35±5   0±0   0±0  
    Expression of skeletal muscle markers   0±0   40±5   65±5  

The numbers represent approximate calculations from at least five transplantation experiments expressed as deviation of the means. Since transplanted cardiomyocytes often formed clusters it was not always possible to count individual cells.

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