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Table 2.

Human SMAD tumor alleles expressed in flies

Allele	Lesion	Codon	Domain	Alteration	Tumor	Reference
SMAD4^100T	Missense	100	MH1	Arg to Thr	Pancreas	Schutte et al., 1996
SMAD4^130S	Missense	130	MH1	Pro to Ser	Colorectal	Thiagalingam et al., 1996
SMAD4^493H	Missense	493	MH2	Asp to His	Pancreas	Hahn et al., 1996
SMAD4^524ST	Nonsense	524	MH2	Cys to Stop	Colorectal	Riggins et al., 1996
SMAD2^Δ344-358	Deletion	344-358	MH2	14aa deletion	Colorectal	Riggins et al., 1996

Allele	Lesion	Codon	Domain	Alteration	Tumor	Reference
SMAD4^100T	Missense	100	MH1	Arg to Thr	Pancreas	Schutte et al., 1996
SMAD4^130S	Missense	130	MH1	Pro to Ser	Colorectal	Thiagalingam et al., 1996
SMAD4^493H	Missense	493	MH2	Asp to His	Pancreas	Hahn et al., 1996
SMAD4^524ST	Nonsense	524	MH2	Cys to Stop	Colorectal	Riggins et al., 1996
SMAD2^Δ344-358	Deletion	344-358	MH2	14aa deletion	Colorectal	Riggins et al., 1996