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Table 1.

New Mad mutant sequences

Allele	Lesion	Codon	Domain	Alteration	Effect^*
Mad¹	Missense	90	MH1	Gln to Leu	Dominant negative
Mad⁵	Missense	272	MH2	Arg to His	Loss of function (hypomorph)
Mad⁶	Missense	272	MH2	Arg to His	Loss of function (hypomorph)
Mad^B65.3	Missense	272	MH2	Arg to His	Loss of function (hypomorph)
Mad⁸	Missense	358	MH2	Ser to Leu	Loss of function (hypomorph)
Mad¹¹	Missense	410	MH2	Gly to Asp	Loss of function (hypomorph)
Mad⁷	Missense	419	MH2	Val to Met	Loss of function (null)

Allele	Lesion	Codon	Domain	Alteration	Effect^*
Mad¹	Missense	90	MH1	Gln to Leu	Dominant negative
Mad⁵	Missense	272	MH2	Arg to His	Loss of function (hypomorph)
Mad⁶	Missense	272	MH2	Arg to His	Loss of function (hypomorph)
Mad^B65.3	Missense	272	MH2	Arg to His	Loss of function (hypomorph)
Mad⁸	Missense	358	MH2	Ser to Leu	Loss of function (hypomorph)
Mad¹¹	Missense	410	MH2	Gly to Asp	Loss of function (hypomorph)
Mad⁷	Missense	419	MH2	Val to Met	Loss of function (null)

Previously reported (Sekelsky et al.,1995), except for Mad¹ and Mad^B65.3.