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Table 1.

Effects of inhibition of POPK-1 function on tissue differentiation

Embryos with expression of markers / embryos examined (%)
Control MO (750 pg)
Hr-POPK-1 MO2 (750 pg)
MarkernNormalReducedNot detectednNormalIncreasedReducedNot detected
Muscle (AChE) 29 (41) 100 (95) 0 (5) 0 (0) 25 (11) 0 (0) 0 (0) 28 (45) 72 (55) 
(Mu-2) 37 (15) 100 (94) 0 (6) 0 (0) 63 (21) 16 (0) 0 (0) 36 (100) 48 (0) 
Mesenchyme (Mch-3) 23 (24) 100 (92) 0 (4) 0 (4) 27 (26) 4 (4) 0 (0) 4 (23) 92 (73) 
Notochord (Not-1) 11 (10) 100 (100) 0 (0) 0 (0) 18 (21)* 78 (48) 0 (0) 0 (33) 22 (19) 
Endoderm (ALP) 15 (26) 100 (100) 0 (0) 0 (0) 25 (26) 84 (85) 0 (15) 16 (0) 0 (0) 
Embryos with expression of markers / embryos examined (%)
Control MO (750 pg)
Hr-POPK-1 MO2 (750 pg)
MarkernNormalReducedNot detectednNormalIncreasedReducedNot detected
Muscle (AChE) 29 (41) 100 (95) 0 (5) 0 (0) 25 (11) 0 (0) 0 (0) 28 (45) 72 (55) 
(Mu-2) 37 (15) 100 (94) 0 (6) 0 (0) 63 (21) 16 (0) 0 (0) 36 (100) 48 (0) 
Mesenchyme (Mch-3) 23 (24) 100 (92) 0 (4) 0 (4) 27 (26) 4 (4) 0 (0) 4 (23) 92 (73) 
Notochord (Not-1) 11 (10) 100 (100) 0 (0) 0 (0) 18 (21)* 78 (48) 0 (0) 0 (33) 22 (19) 
Endoderm (ALP) 15 (26) 100 (100) 0 (0) 0 (0) 25 (26) 84 (85) 0 (15) 16 (0) 0 (0) 

Results of cleavage-arrested embryos are indicated in parentheses.

Highest proportions are indicated in bold.

*

Hr-POPK-1 MO1 was injected.

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