Skip to Main Content
Table 1.

Conduction intervals from wild-type and Tbx5(del/–) mice

A. Electrocardiology*NewbornAdultP-value (newborn:adult)
Wild-type PQ interval 48.0±7.6 41.9±1.0 <0.001 
Tbx5(del/+) PQ interval 50.7±5.8 49.1±4.6 <0.46 
P-value 0.38 <0.01  
Wild-type QRS interval 9.8±1.5 13.7±1.3 <0.01 
Tbx5(del/+) QRS interval 12.7±2.6 16.5±1.0 <0.01 
P-value <0.001 <0.005  
A. Electrocardiology*NewbornAdultP-value (newborn:adult)
Wild-type PQ interval 48.0±7.6 41.9±1.0 <0.001 
Tbx5(del/+) PQ interval 50.7±5.8 49.1±4.6 <0.46 
P-value 0.38 <0.01  
Wild-type QRS interval 9.8±1.5 13.7±1.3 <0.01 
Tbx5(del/+) QRS interval 12.7±2.6 16.5±1.0 <0.01 
P-value <0.001 <0.005  
B. Electrophysiology§Wild-type adultTbx5(del/+) adultP-value (wild-type:Tbx5(del/+))
AH interval 37.0±1.5 42.3±6.0 <0.001 
HV interval 11.5±1.5 10.3±2.0 <0.69 
P-wave duration 15.0±1.1 15.9±2.5 <0.36 
B. Electrophysiology§Wild-type adultTbx5(del/+) adultP-value (wild-type:Tbx5(del/+))
AH interval 37.0±1.5 42.3±6.0 <0.001 
HV interval 11.5±1.5 10.3±2.0 <0.69 
P-wave duration 15.0±1.1 15.9±2.5 <0.36 
*

PQ and QRS intervals were compared in newborn and adult wild-type and Tbx5del/+ mice. The PQ interval is not significantly different between newborn Tbx5del/+ and wild-type mice,but was significantly longer in adult Tbx5del/+ than in adult wild-type mice. Note that the PQ interval of wild-type mice shortens with age, whereas the PQ interval of Tbx5del/+ mice fails to undergo physiologic shortening in the postnatal period. The QRS interval is significantly longer in both newborn and adult Tbx5del/+mice compared with age-matched wild-type mice

Wild-type PQ interval:Tbx5(del/+) PQ interval

Wild-type QRS interval:Tbx5(del/+) QRS interval

§

The AH and HV interval and P-wave duration were compared in adult wild-type and Tbx5del/+ mice. The HV interval and P-wave duration are not significantly different between wild-type and Tbx5del/+ adult mice. However, the AH interval is significantly longer in Tbx5del/+ mice than in wild-type adult mice

Close Modal

or Create an Account

Close Modal
Close Modal