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Table 2.

ILK expression in human malignancies

Malignancy Comments Positivity* (%) Reference
Melanoma   Strong expression of ILK was associated with tissue thickness and was inversely correlated with 5-year survival   95.5   (Dai et al., 2003)  
Colon cancer   ILK expression levels correlated with tumor invasion, grade and stage; higher levels in metastatic tumors, no staining in normal epithelium   97.5   (Bravou et al., 2003)  
Colon cancer   Overexpression of ILK in malignant acini compared with normal crypts    (Marotta et al., 2003)  
Colon cancer   ILK expression levels correlated with tumor invasion, grade and stage; higher levels in metastatic tumors   98.4   (Bravou et al., 2006)  
Colorectal cancer   ILK expression in the majority of tumors   80   (Huang et al., 2007)  
Gastric cancer   Strong expression in the majority of primary tumors that were associated with tumor cell invasion and nodal metastasis; no expression in non-neoplastic gastric epithelia   69   (Ito et al., 2003)  
Non-small-cell lung cancer   ILK expression significantly associated with tumor grade and stage, and lower 5-year survival; ILK expression indicates a poor prognosis   96   (Takanami, 2005)  
Non-small-cell lung cancer   Strong cytoplasmic staining in a subset of tumors that is associated with poor prognosis   24.5   (Okamura et al., 2007)  
Anaplastic thyroid cancer   ILK highly expressed in tumor tissue, but not in normal thyroid tissue   81   (Younes et al., 2005)  
Squamous cell carcinoma of head and neck   Tumors stained for ILK; normal tongue tissue was negative for ILK; ILK is overexpressed in tumors   88.2   (Younes et al., 2007)  
Pancreatic cancer   Strong ILK expression was a significant (negative) prognostic indicator   65   (Sawai et al., 2006)  
Ovarian cancer   ILK expression increased with tumor progression; normal epithelium was negative for ILK   100   (Ahmed et al., 2003)  
Prostate cancer   ILK expression increased with tumor progression; inversely correlated with 5-year survival   44   (Graff et al., 2001)  
Mesothelioma   ILK expression at varying levels in tumor samples; normal mesothelial cells and lung parenchyma were negative   87.9   (Watzka et al., 2008)  
Ewing sarcoma   Expression observed in all samples   100   (Chung et al., 1998)  
Primitive neuroectodermal tumor   Expression observed in all samples   100   (Chung et al., 1998)  
Medulloblastoma   Expression observed in all samples   100   (Chung et al., 1998)  
Malignancy Comments Positivity* (%) Reference
Melanoma   Strong expression of ILK was associated with tissue thickness and was inversely correlated with 5-year survival   95.5   (Dai et al., 2003)  
Colon cancer   ILK expression levels correlated with tumor invasion, grade and stage; higher levels in metastatic tumors, no staining in normal epithelium   97.5   (Bravou et al., 2003)  
Colon cancer   Overexpression of ILK in malignant acini compared with normal crypts    (Marotta et al., 2003)  
Colon cancer   ILK expression levels correlated with tumor invasion, grade and stage; higher levels in metastatic tumors   98.4   (Bravou et al., 2006)  
Colorectal cancer   ILK expression in the majority of tumors   80   (Huang et al., 2007)  
Gastric cancer   Strong expression in the majority of primary tumors that were associated with tumor cell invasion and nodal metastasis; no expression in non-neoplastic gastric epithelia   69   (Ito et al., 2003)  
Non-small-cell lung cancer   ILK expression significantly associated with tumor grade and stage, and lower 5-year survival; ILK expression indicates a poor prognosis   96   (Takanami, 2005)  
Non-small-cell lung cancer   Strong cytoplasmic staining in a subset of tumors that is associated with poor prognosis   24.5   (Okamura et al., 2007)  
Anaplastic thyroid cancer   ILK highly expressed in tumor tissue, but not in normal thyroid tissue   81   (Younes et al., 2005)  
Squamous cell carcinoma of head and neck   Tumors stained for ILK; normal tongue tissue was negative for ILK; ILK is overexpressed in tumors   88.2   (Younes et al., 2007)  
Pancreatic cancer   Strong ILK expression was a significant (negative) prognostic indicator   65   (Sawai et al., 2006)  
Ovarian cancer   ILK expression increased with tumor progression; normal epithelium was negative for ILK   100   (Ahmed et al., 2003)  
Prostate cancer   ILK expression increased with tumor progression; inversely correlated with 5-year survival   44   (Graff et al., 2001)  
Mesothelioma   ILK expression at varying levels in tumor samples; normal mesothelial cells and lung parenchyma were negative   87.9   (Watzka et al., 2008)  
Ewing sarcoma   Expression observed in all samples   100   (Chung et al., 1998)  
Primitive neuroectodermal tumor   Expression observed in all samples   100   (Chung et al., 1998)  
Medulloblastoma   Expression observed in all samples   100   (Chung et al., 1998)  
*

The number of samples that stained for ILK, expressed as a percentage

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