ILK expression in human malignancies
| Malignancy . | Comments . | Positivity* (%) . | Reference . |
|---|---|---|---|
| Melanoma | Strong expression of ILK was associated with tissue thickness and was inversely correlated with 5-year survival | 95.5 | (Dai et al., 2003) |
| Colon cancer | ILK expression levels correlated with tumor invasion, grade and stage; higher levels in metastatic tumors, no staining in normal epithelium | 97.5 | (Bravou et al., 2003) |
| Colon cancer | Overexpression of ILK in malignant acini compared with normal crypts | (Marotta et al., 2003) | |
| Colon cancer | ILK expression levels correlated with tumor invasion, grade and stage; higher levels in metastatic tumors | 98.4 | (Bravou et al., 2006) |
| Colorectal cancer | ILK expression in the majority of tumors | 80 | (Huang et al., 2007) |
| Gastric cancer | Strong expression in the majority of primary tumors that were associated with tumor cell invasion and nodal metastasis; no expression in non-neoplastic gastric epithelia | 69 | (Ito et al., 2003) |
| Non-small-cell lung cancer | ILK expression significantly associated with tumor grade and stage, and lower 5-year survival; ILK expression indicates a poor prognosis | 96 | (Takanami, 2005) |
| Non-small-cell lung cancer | Strong cytoplasmic staining in a subset of tumors that is associated with poor prognosis | 24.5 | (Okamura et al., 2007) |
| Anaplastic thyroid cancer | ILK highly expressed in tumor tissue, but not in normal thyroid tissue | 81 | (Younes et al., 2005) |
| Squamous cell carcinoma of head and neck | Tumors stained for ILK; normal tongue tissue was negative for ILK; ILK is overexpressed in tumors | 88.2 | (Younes et al., 2007) |
| Pancreatic cancer | Strong ILK expression was a significant (negative) prognostic indicator | 65 | (Sawai et al., 2006) |
| Ovarian cancer | ILK expression increased with tumor progression; normal epithelium was negative for ILK | 100 | (Ahmed et al., 2003) |
| Prostate cancer | ILK expression increased with tumor progression; inversely correlated with 5-year survival | 44 | (Graff et al., 2001) |
| Mesothelioma | ILK expression at varying levels in tumor samples; normal mesothelial cells and lung parenchyma were negative | 87.9 | (Watzka et al., 2008) |
| Ewing sarcoma | Expression observed in all samples | 100 | (Chung et al., 1998) |
| Primitive neuroectodermal tumor | Expression observed in all samples | 100 | (Chung et al., 1998) |
| Medulloblastoma | Expression observed in all samples | 100 | (Chung et al., 1998) |
| Malignancy . | Comments . | Positivity* (%) . | Reference . |
|---|---|---|---|
| Melanoma | Strong expression of ILK was associated with tissue thickness and was inversely correlated with 5-year survival | 95.5 | (Dai et al., 2003) |
| Colon cancer | ILK expression levels correlated with tumor invasion, grade and stage; higher levels in metastatic tumors, no staining in normal epithelium | 97.5 | (Bravou et al., 2003) |
| Colon cancer | Overexpression of ILK in malignant acini compared with normal crypts | (Marotta et al., 2003) | |
| Colon cancer | ILK expression levels correlated with tumor invasion, grade and stage; higher levels in metastatic tumors | 98.4 | (Bravou et al., 2006) |
| Colorectal cancer | ILK expression in the majority of tumors | 80 | (Huang et al., 2007) |
| Gastric cancer | Strong expression in the majority of primary tumors that were associated with tumor cell invasion and nodal metastasis; no expression in non-neoplastic gastric epithelia | 69 | (Ito et al., 2003) |
| Non-small-cell lung cancer | ILK expression significantly associated with tumor grade and stage, and lower 5-year survival; ILK expression indicates a poor prognosis | 96 | (Takanami, 2005) |
| Non-small-cell lung cancer | Strong cytoplasmic staining in a subset of tumors that is associated with poor prognosis | 24.5 | (Okamura et al., 2007) |
| Anaplastic thyroid cancer | ILK highly expressed in tumor tissue, but not in normal thyroid tissue | 81 | (Younes et al., 2005) |
| Squamous cell carcinoma of head and neck | Tumors stained for ILK; normal tongue tissue was negative for ILK; ILK is overexpressed in tumors | 88.2 | (Younes et al., 2007) |
| Pancreatic cancer | Strong ILK expression was a significant (negative) prognostic indicator | 65 | (Sawai et al., 2006) |
| Ovarian cancer | ILK expression increased with tumor progression; normal epithelium was negative for ILK | 100 | (Ahmed et al., 2003) |
| Prostate cancer | ILK expression increased with tumor progression; inversely correlated with 5-year survival | 44 | (Graff et al., 2001) |
| Mesothelioma | ILK expression at varying levels in tumor samples; normal mesothelial cells and lung parenchyma were negative | 87.9 | (Watzka et al., 2008) |
| Ewing sarcoma | Expression observed in all samples | 100 | (Chung et al., 1998) |
| Primitive neuroectodermal tumor | Expression observed in all samples | 100 | (Chung et al., 1998) |
| Medulloblastoma | Expression observed in all samples | 100 | (Chung et al., 1998) |
The number of samples that stained for ILK, expressed as a percentage