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Table 2.

unc-115 acts with the three rac genes andunc-73 in PDE* and CAN axon pathfinding

GenotypePercent ventral axon guidance errorsPercent ectopic axonsPercent posterior CAN axon outgrowth defectsPercent CAN cell migration defects§
3±3 5±4 
unc-115(mn481) 5±5 5±4 
unc-115(ky275) 20±5 10±4 
unc-115(mn481); ced-10(n1993) 9±4 22±5 22±7 8±5 
unc-115(ky275); ced-10(n1993) 10±4 18±5 25±6 12±4 
unc-115(mn481) mig-2(mu28) 13±4 24±6 21±7 15±7 
unc-115(ky275) mig-2(mu28) 15±5 20±5 21±6 10±5 
unc-115(mn481); rac-2/3(RNAi) 4±5 10±5 
unc-115(ky275); rac-2/3(RNAi) 22±8 9±5 
unc-73(e936) 35±9 21±7 29±8 77±8 
unc-73(rh40) 23±5 25±5 39±8 49±9 
unc-73(e936); unc-115(ky275) 62±6 29±5 62±7 70±6 
unc-73(e936); unc-115(mn481) 58±5 34±4 67±6 72±6 
unc-73(rh40); unc-115(ky275) 58±7 27±5 59±8 55±8 
unc-73(rh40); unc-115(mn481) 50±6 33±5 86±5 54±6 
unc-73(e936); unc-115(ky275); rac-2/3(RNAi) 66±4 37±5 N.D. N.D. 
unc-73(rh40); unc-115(ky275); rac-2/3(RNAi) 53±7 31±5 N.D. N.D. 
GenotypePercent ventral axon guidance errorsPercent ectopic axonsPercent posterior CAN axon outgrowth defectsPercent CAN cell migration defects§
3±3 5±4 
unc-115(mn481) 5±5 5±4 
unc-115(ky275) 20±5 10±4 
unc-115(mn481); ced-10(n1993) 9±4 22±5 22±7 8±5 
unc-115(ky275); ced-10(n1993) 10±4 18±5 25±6 12±4 
unc-115(mn481) mig-2(mu28) 13±4 24±6 21±7 15±7 
unc-115(ky275) mig-2(mu28) 15±5 20±5 21±6 10±5 
unc-115(mn481); rac-2/3(RNAi) 4±5 10±5 
unc-115(ky275); rac-2/3(RNAi) 22±8 9±5 
unc-73(e936) 35±9 21±7 29±8 77±8 
unc-73(rh40) 23±5 25±5 39±8 49±9 
unc-73(e936); unc-115(ky275) 62±6 29±5 62±7 70±6 
unc-73(e936); unc-115(mn481) 58±5 34±4 67±6 72±6 
unc-73(rh40); unc-115(ky275) 58±7 27±5 59±8 55±8 
unc-73(rh40); unc-115(mn481) 50±6 33±5 86±5 54±6 
unc-73(e936); unc-115(ky275); rac-2/3(RNAi) 66±4 37±5 N.D. N.D. 
unc-73(rh40); unc-115(ky275); rac-2/3(RNAi) 53±7 31±5 N.D. N.D. 
*

PDE axons were scored as described inTable 1. 

CAN axon morphology and cell body position was assessed using the integrated transgene lqIs10[ceh-10::gfp](Lundquist et al., 2001).

The percentage of posterior CAN axons that failed to extend past the post-deirid ganglion is shown (±2× standard error of the proportion) (see Lundquist et al.,2001).

§

The percentage of CAN cell bodies that failed to reach the region of the vulva (±2× standard error of the proportion) (seeLundquist et al., 2001).

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