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Table 1.

ced-10, mig-2, rac-2/3 and unc-73 act in PDE* axon pathfinding

GenotypePercent ventral axon guidance errorsPercent ectopic axons
3±3 
ced-10(n1993) 2±2 
mig-2(mu28) 1±2 6±3 
mig-2(gm38mu133) 1±2 4±3 
rac-2/3(RNAi) 2±5 
ced-10(n1993M+);mig-2(mu28)§ 65±9 21±8 
ced-10(n1993M+); mig-2(gm38mu133) 55±9 23±7 
ced-10(n1993); rac-2/3(RNAi) 12±5 22±6 
mig-2(mu28); rac-2/3(RNAi) 18±5 19±5 
mig-2(gm38mu133); rac-2/3(RNAi) 21±7 15±6 
unc-73(e936) 35±6 21±6 
unc-73(rh40) 24±4 28±4 
unc-73(e936); ced-10(n1993) 86±3 51±5 
unc-73(e936); mig-2(mu28) 71±4 68±4 
unc-73(e936); rac-2/3(RNAi) 55±5 67±4 
unc-73(rh40); ced-10(n1993) 72±5 37±5 
unc-73(rh40); mig-2(mu28) 63±5 46±5 
unc-73(rh40); rac-2/3(RNAi) 50±5 38±5 
unc-73(rh40); lqEx48 (rac-2(G12V) 9±3 85±4 
GenotypePercent ventral axon guidance errorsPercent ectopic axons
3±3 
ced-10(n1993) 2±2 
mig-2(mu28) 1±2 6±3 
mig-2(gm38mu133) 1±2 4±3 
rac-2/3(RNAi) 2±5 
ced-10(n1993M+);mig-2(mu28)§ 65±9 21±8 
ced-10(n1993M+); mig-2(gm38mu133) 55±9 23±7 
ced-10(n1993); rac-2/3(RNAi) 12±5 22±6 
mig-2(mu28); rac-2/3(RNAi) 18±5 19±5 
mig-2(gm38mu133); rac-2/3(RNAi) 21±7 15±6 
unc-73(e936) 35±6 21±6 
unc-73(rh40) 24±4 28±4 
unc-73(e936); ced-10(n1993) 86±3 51±5 
unc-73(e936); mig-2(mu28) 71±4 68±4 
unc-73(e936); rac-2/3(RNAi) 55±5 67±4 
unc-73(rh40); ced-10(n1993) 72±5 37±5 
unc-73(rh40); mig-2(mu28) 63±5 46±5 
unc-73(rh40); rac-2/3(RNAi) 50±5 38±5 
unc-73(rh40); lqEx48 (rac-2(G12V) 9±3 85±4 
*

PDE axon morphology was scored using the integrated transgenelqIs3[osm-6::gfp].

The percent of PDE axons that failed to reach the ventral nerve cord(±2× standard error of the proportion).

The percent of PDE axons that exhibited ectopic axons emanating from the cell body or branching from the main axon (±2× standard error of the proportion).

§

M+ indicates that these animals were homozygous for n1993, but were derived from mothers heterozygous for n1993, and therefore retain wild-type maternal ced-10 activity.

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