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Table 2.

hlh-14 loss induces HSN neuron loss

Number of HSN neurons/side
Genotype01n
Wild-type adults* 0% 100% 100 
hlh-14(gm34)adults* 83% 17% 23 
hlh-14(RNAi)adults* 27% 73% 180 
Wild-type larvae 0% 100% 66 
hlh-14(gm34)larvae 100% 0% 28 
hlh-14(RNAi)larvae 45% 55% 130 
Number of HSN neurons/side
Genotype01n
Wild-type adults* 0% 100% 100 
hlh-14(gm34)adults* 83% 17% 23 
hlh-14(RNAi)adults* 27% 73% 180 
Wild-type larvae 0% 100% 66 
hlh-14(gm34)larvae 100% 0% 28 
hlh-14(RNAi)larvae 45% 55% 130 
*

HSNs stained with an anti-serotonin antibody in adults.

HSNs expressing unc-86::gfp in L1 larvae.

It is possible that additional HSN neurons did express unc-86::gfpin hlh-14 mutant larvae,but were completely migration defective. These HSNs would have been located in the tail among other neurons expressing unc-86::gfp and would not have been detected and counted. Supporting this possibility, many of the HSNs detected by anti-serotonin staining were located the tail, having failed to migrate.

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