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Table 1.

Cardiovascular phenotypes of Fgf8 domain-specific mutants:sectioned specimens at E18.5

Phenotype
GenotypeNormalIAABCircumflex/RAARERSCA/abnormal SCACoronary artery anomaly*Bicuspid aortic valveOther
AP/+ or +/N (n=40) 40 (100%) 
AP/N (n=15) 15 (100%) 
AP/N; AP2α-ICre (n=24) 1 (5%) 7 (30%) 3 (13%) Nineteen associated (80%), four isolated (17%) 11 (46%) 4 (16%) 
AP/N; hoxa3-ICre (n=33) 2 (6%) 5 (15%) 3 (9%) Seventeen associated (52%), five isolated (15%) 18 (55%) 7 (23%) 4 (13%) 
P value (Ap2α versus hoxa3mutants) NS NS NS 0.05 NS <0.02 NS 
Phenotype
GenotypeNormalIAABCircumflex/RAARERSCA/abnormal SCACoronary artery anomaly*Bicuspid aortic valveOther
AP/+ or +/N (n=40) 40 (100%) 
AP/N (n=15) 15 (100%) 
AP/N; AP2α-ICre (n=24) 1 (5%) 7 (30%) 3 (13%) Nineteen associated (80%), four isolated (17%) 11 (46%) 4 (16%) 
AP/N; hoxa3-ICre (n=33) 2 (6%) 5 (15%) 3 (9%) Seventeen associated (52%), five isolated (15%) 18 (55%) 7 (23%) 4 (13%) 
P value (Ap2α versus hoxa3mutants) NS NS NS 0.05 NS <0.02 NS 

IAAB, interrupted aortic arch type B; circumflex/RA, circumflex right aortic arch or right aortic arch; RERSCA/abnormal SCA, retroesophageal right subclavian artery, abnormal subclavian branching, including right and/or left subclavian arteries. Some category numbers exceed the total number examined because of multiple phenotypes in single animals.

*

Majority in all genotypes was single coronary off right anterior cusp

Fisher's exact test, two-tailed

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