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Table 1.

Known binding partners for selected desmosomal proteins

Desmosomal proteins Binding partners Level of evidence Refs
Desmocollin 1 (Dsc1)   Dsg1   IV   (Kami et al., 2009)  
  Dsg2   IP, IV   (Chitaev et al., 1997)  
  DP   IV   (Smith and Fuchs, 1998)  
  Pg   Y2H, IP   (Cheng et al., 2004; Troyanovsky et al., 1994)  
  Pkp1   Y2H   (Cheng et al., 2004)  
  Pkp2   Y2H   (Chen et al., 2002)  
  Pkp3   Y2H   (Bonne et al., 2003)  
Desmoglein 1 (Dsg1)   Dsc1   IV   (Kami et al., 2009)  
  DP   IV   (Kami et al., 2009)  
  Pg   IP, IV   (Kowalczyk et al., 1996; Smith and Fuchs, 1998)  
  Pkp1   IV   (Smith and Fuchs, 1998)  
  Pkp2   Y2H, IP   (Chen et al., 2002)  
  Pkp3   IP, IV   (Bonne et al., 2003)  
  SSSCA1   IP   (Ewing et al., 2007)  
Desmoplakin (DP)   Desmin   Y2H   (Meng et al., 1997)  
  Dsc1   IV   (Smith and Fuchs, 1998)  
  DP   Y2H, IV   (Choi et al., 2002; Meng et al., 1997)  
  IKBKE   IP   (Bouwmeester et al., 2004)  
  Keratin-1, -8, -18   Y2H, IV   (Meng et al., 1997)  
  NFKB1, NFKB2, NFKBIB   IP   (Bouwmeester et al., 2004)  
  P0071   Y2H, IP   (Calkins et al., 2003)  
  PECAM-1   IP   (Ilan et al., 2000)  
  Pg   Y2H, IP   (Kowalczyk et al., 1997)  
  Pkp1-Pkp3   Y2H, IP, IV   (Bonne et al., 2003; Chen et al., 2002; Hofmann et al., 2000)  
  RELB   IP   (Bouwmeester et al., 2004)  
  STK24 (STE20)   IP   (Ewing et al., 2007)  
  Vimentin   Y2H, IV   (Choi et al., 2002; Meng et al., 1997)  
Plakoglobin (Pg)   α-catenin   IV   (Aberle et al., 1994)  
  APC   Y2H, IP, IV   (Rubinfeld et al., 1995)  
  ARHGDIA   Y2H   (Stelzl et al., 2005)  
  β-TrCP   IP   (Sadot et al., 2000)  
  BIRC2   Y2H   (Rual et al., 2005)  
  DEP1   GST   (Holsinger et al., 2002)  
Pg (cont'd)   Dsc1   IP   (Witcher et al., 1996)  
  Dsc2   IP   (Kowalczyk et al., 1996)  
  Dsc3   IP   (Hanakawa et al., 2000)  
  Dsg1   IP, IV   (Kowalczyk et al., 1996; Smith and Fuchs, 1998)  
  Dsg2   IP, IV   (Bannon et al., 2001; Ozawa et al., 1995)  
  Dsg3   IP, IV   (Roh et al., 1995)  
  DP   Y2H, IP   (Kowalczyk et al., 1997)  
  DF3/MUC1   IP, IV   (Yamamoto et al., 1997)  
  E-cadherin   IP, IV   (Aberle et al., 1994; Knudsen et al., 1992; Sacco et al., 1995; Rubinfeld et al., 1995)  
  ErbB2   IP, IV   (Ochai et al., 1994; Kanai et al., 1995)  
  ICAT   Y2H   (Rual et al., 2005)  
  LGALS9   IP   (Ewing et al., 2007)  
  N-cadherin   IP   (Knudsen et al., 1992)  
  NFKBIE   Y2H   (Rual et al., 2005)  
  P-cadherin   IP   (Klingelhofer et al., 2000)  
  PECAM-1   GST, IP   (Ilan et al., 2000)  
  PHB2   IP   (Ewing et al., 2007)  
  Pg   IP, IV   (Kowalczyk et al., 1996; Smith and Fuchs, 1998)  
  Pkp2   Y2H, IP   (Chen et al., 2002)  
  PTPκ   GST, IP   (Fuchs et al., 1996)  
  PTPRF   GST   (Aicher et al., 1997)  
  RIBC2   Y2H   (Rual et al., 2005)  
  Tcf-4   IV   (Miravet et al., 2002  
  VE-cadherin   IP   (Lampugnani et al., 1995)  
  WDYHV1   Y2H   (Rual et al., 2005)  
Plakophilin 2 (Pkp2)   14-3-3   IP   (Benzinger et al., 2005)  
  β-catenin   Y2H, IP   (Chen et al., 2002)  
  Cytokeratins 5, 8, 14, 18   IV   (Hofmann et al., 2000)  
  Dsc1   Y2H, IP   (Chen et al., 2002)  
  Dsc2   Y2H, IP   (Chen et al., 2002)  
  Dsg1   Y2H, IP   (Chen et al., 2002)  
  Dsg2   Y2H, IP   (Chen et al., 2002)  
  DP   IP   (Chen et al., 2002)  
  Pg   Y2H, IP   (Chen et al., 2002)  
  RPC155   IP, IV   (Mertens et al., 2001)  
  TFIIIB   IP   (Mertens et al., 2001)  
  Vimentin   IV   (Hofmann et al., 2000)  
Desmosomal proteins Binding partners Level of evidence Refs
Desmocollin 1 (Dsc1)   Dsg1   IV   (Kami et al., 2009)  
  Dsg2   IP, IV   (Chitaev et al., 1997)  
  DP   IV   (Smith and Fuchs, 1998)  
  Pg   Y2H, IP   (Cheng et al., 2004; Troyanovsky et al., 1994)  
  Pkp1   Y2H   (Cheng et al., 2004)  
  Pkp2   Y2H   (Chen et al., 2002)  
  Pkp3   Y2H   (Bonne et al., 2003)  
Desmoglein 1 (Dsg1)   Dsc1   IV   (Kami et al., 2009)  
  DP   IV   (Kami et al., 2009)  
  Pg   IP, IV   (Kowalczyk et al., 1996; Smith and Fuchs, 1998)  
  Pkp1   IV   (Smith and Fuchs, 1998)  
  Pkp2   Y2H, IP   (Chen et al., 2002)  
  Pkp3   IP, IV   (Bonne et al., 2003)  
  SSSCA1   IP   (Ewing et al., 2007)  
Desmoplakin (DP)   Desmin   Y2H   (Meng et al., 1997)  
  Dsc1   IV   (Smith and Fuchs, 1998)  
  DP   Y2H, IV   (Choi et al., 2002; Meng et al., 1997)  
  IKBKE   IP   (Bouwmeester et al., 2004)  
  Keratin-1, -8, -18   Y2H, IV   (Meng et al., 1997)  
  NFKB1, NFKB2, NFKBIB   IP   (Bouwmeester et al., 2004)  
  P0071   Y2H, IP   (Calkins et al., 2003)  
  PECAM-1   IP   (Ilan et al., 2000)  
  Pg   Y2H, IP   (Kowalczyk et al., 1997)  
  Pkp1-Pkp3   Y2H, IP, IV   (Bonne et al., 2003; Chen et al., 2002; Hofmann et al., 2000)  
  RELB   IP   (Bouwmeester et al., 2004)  
  STK24 (STE20)   IP   (Ewing et al., 2007)  
  Vimentin   Y2H, IV   (Choi et al., 2002; Meng et al., 1997)  
Plakoglobin (Pg)   α-catenin   IV   (Aberle et al., 1994)  
  APC   Y2H, IP, IV   (Rubinfeld et al., 1995)  
  ARHGDIA   Y2H   (Stelzl et al., 2005)  
  β-TrCP   IP   (Sadot et al., 2000)  
  BIRC2   Y2H   (Rual et al., 2005)  
  DEP1   GST   (Holsinger et al., 2002)  
Pg (cont'd)   Dsc1   IP   (Witcher et al., 1996)  
  Dsc2   IP   (Kowalczyk et al., 1996)  
  Dsc3   IP   (Hanakawa et al., 2000)  
  Dsg1   IP, IV   (Kowalczyk et al., 1996; Smith and Fuchs, 1998)  
  Dsg2   IP, IV   (Bannon et al., 2001; Ozawa et al., 1995)  
  Dsg3   IP, IV   (Roh et al., 1995)  
  DP   Y2H, IP   (Kowalczyk et al., 1997)  
  DF3/MUC1   IP, IV   (Yamamoto et al., 1997)  
  E-cadherin   IP, IV   (Aberle et al., 1994; Knudsen et al., 1992; Sacco et al., 1995; Rubinfeld et al., 1995)  
  ErbB2   IP, IV   (Ochai et al., 1994; Kanai et al., 1995)  
  ICAT   Y2H   (Rual et al., 2005)  
  LGALS9   IP   (Ewing et al., 2007)  
  N-cadherin   IP   (Knudsen et al., 1992)  
  NFKBIE   Y2H   (Rual et al., 2005)  
  P-cadherin   IP   (Klingelhofer et al., 2000)  
  PECAM-1   GST, IP   (Ilan et al., 2000)  
  PHB2   IP   (Ewing et al., 2007)  
  Pg   IP, IV   (Kowalczyk et al., 1996; Smith and Fuchs, 1998)  
  Pkp2   Y2H, IP   (Chen et al., 2002)  
  PTPκ   GST, IP   (Fuchs et al., 1996)  
  PTPRF   GST   (Aicher et al., 1997)  
  RIBC2   Y2H   (Rual et al., 2005)  
  Tcf-4   IV   (Miravet et al., 2002  
  VE-cadherin   IP   (Lampugnani et al., 1995)  
  WDYHV1   Y2H   (Rual et al., 2005)  
Plakophilin 2 (Pkp2)   14-3-3   IP   (Benzinger et al., 2005)  
  β-catenin   Y2H, IP   (Chen et al., 2002)  
  Cytokeratins 5, 8, 14, 18   IV   (Hofmann et al., 2000)  
  Dsc1   Y2H, IP   (Chen et al., 2002)  
  Dsc2   Y2H, IP   (Chen et al., 2002)  
  Dsg1   Y2H, IP   (Chen et al., 2002)  
  Dsg2   Y2H, IP   (Chen et al., 2002)  
  DP   IP   (Chen et al., 2002)  
  Pg   Y2H, IP   (Chen et al., 2002)  
  RPC155   IP, IV   (Mertens et al., 2001)  
  TFIIIB   IP   (Mertens et al., 2001)  
  Vimentin   IV   (Hofmann et al., 2000)  

14-3-3, stratifin; APC, adenomatous polyposis coli; ARHGDIA (RHOGDI-1), Rho GDP dissociation inhibitor (GDI) alpha; β-TrCP, β-transducin repeat containing; BIRC2, baculoviral IAP repeat-containing 2; DEP1, protein tyrosine phosphatase receptor type J; DF3/MUC1, mucin 1, cell-surface associated; ErbB2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); GST, glutathione-S-transferase; ICAT, catenin β-interacting protein 1; IKBKE, inhibitor of kappa light polypeptide gene enhancer in B-cells kinase epsilon; IP, immunoprecipitation; IV, in vitro; LGALS9, lectin galactoside-binding soluble 9; NFKB, nuclear factor of kappa light polypeptide gene enhancer in B-cells; NFKBIB, NFKB inhibitor, beta; NFKBIE, NFKB inhibitor epsilon; P0071, plakophilin 4; PECAM-1, platelet/endothelial cell-adhesion molecule; PHB2, prohibitin 2; PTPκ, protein tyrosine phosphatase receptor type κ; PTPRF, protein tyrosine phosphatase receptor type F; RELB, v-rel reticuloendotheliosis viral oncogene homolog B; RIBC2, RIB43A domain with coiled-coils 2; RPC155, DNA-directed RNA polymerase III subunit RPC1; SSSCA1, Sjogren syndrome/scleroderma autoantigen 1; STK24 (STE20), serine/threonine kinase 24 (STE20 homolog, yeast); Tcf-4, transcription factor 4; TFIIIB, B double prime 1 subunit of RNA polymerase III transcription initiation factor IIIB; WDYHV1, WDYHV motif-containing 1; Y2H, yeast two hybrid

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