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Table 1.

Analysis of vascular defects TIE-angiomotin transgenic mice

Age of mice n TIE-angiomotin Phenotype
E9.5   19   +   No detectable phenotype  
E13.5   48   +   No detectable phenotype  
New born pups   130   +   No detectable phenotype, fertile  
Total   197   +   No detectable phenotype  
Age of mice n TIE-angiomotin Phenotype
E9.5   19   +   No detectable phenotype  
E13.5   48   +   No detectable phenotype  
New born pups   130   +   No detectable phenotype, fertile  
Total   197   +   No detectable phenotype  

Heterozygote TIE-angiomotin mice were mated and the DNA from the resulting embryos and newborn pups was analyzed by Southern blot for transgene integration. The vascular phenotype of embryos was analyzed by whole-mount PECAM staining. The animals used in this experiment stem from two independent founder transgenic lines.

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