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Table 1.

Components of Fat-Warts signaling in Drosophila and mouse

Drosophila nameMouse nameProtein type
Dachsous (Ds) Dsch1, Dsch2 Transmembrane ligand 
Fat Fat4 Transmembrane receptor 
 CD44 Transmembrane receptor 
Four-jointed (Fj) Fjx1 Golgi Ser/Thr kinase 
Discs overgrown (Dco) CKIδ, CKIϵ Casein kinase family, Ser/Thr kinase 
Dachs  Unconventional myosin 
Atrophin/Grunge Atrophin Transcriptional co-repressor 
Expanded (Ex) Ex1/Frmd6, Ex2 FERM-domain protein 
Merlin (Mer) Merlin FERM-domain protein 
Hippo (Hpo) Mst1, Mst2 Sterile-20 family, Ser/Thr kinase 
Salvador (sav) WW45 (Sav1) Scaffolding protein 
Warts (Wts) Lats1, Lats2 Nuclear Dbf2-related (NDR) family Ser/Thr kinase 
Mob as tumor suppressor (Mats) Mob1, Mob2 NDR kinase family co-factor 
Yorkie (Yki) Yes-associated protein (Yap) Transcriptional co-activator 
Scalloped (Sd) Tead/Tef1-Tef4 DNA binding 
Drosophila nameMouse nameProtein type
Dachsous (Ds) Dsch1, Dsch2 Transmembrane ligand 
Fat Fat4 Transmembrane receptor 
 CD44 Transmembrane receptor 
Four-jointed (Fj) Fjx1 Golgi Ser/Thr kinase 
Discs overgrown (Dco) CKIδ, CKIϵ Casein kinase family, Ser/Thr kinase 
Dachs  Unconventional myosin 
Atrophin/Grunge Atrophin Transcriptional co-repressor 
Expanded (Ex) Ex1/Frmd6, Ex2 FERM-domain protein 
Merlin (Mer) Merlin FERM-domain protein 
Hippo (Hpo) Mst1, Mst2 Sterile-20 family, Ser/Thr kinase 
Salvador (sav) WW45 (Sav1) Scaffolding protein 
Warts (Wts) Lats1, Lats2 Nuclear Dbf2-related (NDR) family Ser/Thr kinase 
Mob as tumor suppressor (Mats) Mob1, Mob2 NDR kinase family co-factor 
Yorkie (Yki) Yes-associated protein (Yap) Transcriptional co-activator 
Scalloped (Sd) Tead/Tef1-Tef4 DNA binding 
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