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Table 2.

Meiotic defects in CTCF-depleted oocytes

16 hours*
LineGenotype0 hours* %SN-type (n)1 hour* % GVBD(n)2 hours* % GVBD(n)% Ana/telo 1 (n)% PBE (n)
Ntg 68.7 (131) 26.0 (50) 76.0 (50) 9.5 (63) 55.6 (63) 
 Tg 48.0 (98) 2.0 (50) 74.0 (50) 16.1 (62) 32.3 (62) 
  P<0.01 P<0.001 P=1 P=0.3 P<0.05 
12 Ntg 64.5 (110) ND ND 3.2 (62) 38.7 (62) 
 Tg 57.6 (92) ND ND 6.2 (81) 24.7 (81) 
  P=0.384   P=0.7 P=0.099 
21 Ntg 81.5 (119) ND ND 4.8 (62) 58.1 (62) 
 Tg 64.9 (111) ND ND 12.1 (66) 28.8 (66) 
  P<0.01   P=0.21 P<0.01 
16 hours*
LineGenotype0 hours* %SN-type (n)1 hour* % GVBD(n)2 hours* % GVBD(n)% Ana/telo 1 (n)% PBE (n)
Ntg 68.7 (131) 26.0 (50) 76.0 (50) 9.5 (63) 55.6 (63) 
 Tg 48.0 (98) 2.0 (50) 74.0 (50) 16.1 (62) 32.3 (62) 
  P<0.01 P<0.001 P=1 P=0.3 P<0.05 
12 Ntg 64.5 (110) ND ND 3.2 (62) 38.7 (62) 
 Tg 57.6 (92) ND ND 6.2 (81) 24.7 (81) 
  P=0.384   P=0.7 P=0.099 
21 Ntg 81.5 (119) ND ND 4.8 (62) 58.1 (62) 
 Tg 64.9 (111) ND ND 12.1 (66) 28.8 (66) 
  P<0.01   P=0.21 P<0.01 

SN-type, surrounded nucleolus-type GV oocytes.

GVBD, germinal vesicle breakdown.

Ana/telo 1, anaphase or telophase of meiosis 1.

PBE, polar body extrusion.

Ntg, non-transgenic; Tg, transgenic.

n, number of oocytes.

ND, not determined.

*

Germinal vesicle (GV) oocytes were cultured for the indicated number of hours.

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