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Table 1.

Zebrafish mutants with embryonic hepatomegaly

LineGeneMutant nameGene ontogeny and functionCell sizeExtracellular spacePathology
hi2499A vps18 vps18 Conserved to yeast; vacuolar sorting protein Large Expanded ARC syndrome-like 
hi3332 nf2 nf2 Conserved in metazoa; tumor suppressor Wild type Expanded Choledochal cysts type I and II 
hi1532B foie gras foie gras (fgr) Conserved in metazoa; novel Large Wild type Steatosis 
hi3237 thoc2 thoc2 Conserved to yeast; couples mitotic recombination, transcription and RNA export Large Wild type None observed 
hi3785 γ-tubulin γ-tub Conserved to yeast; centrosome protein Large Wild type None observed 
hi1134 sox9a jelly fish (jef) Conserved in metazoa; tissue specific transcription factor Wild type Wild type None observed 
hi1858A paté paté (pté) Conserved to yeast; novel Wild type Wild type None observed 
LineGeneMutant nameGene ontogeny and functionCell sizeExtracellular spacePathology
hi2499A vps18 vps18 Conserved to yeast; vacuolar sorting protein Large Expanded ARC syndrome-like 
hi3332 nf2 nf2 Conserved in metazoa; tumor suppressor Wild type Expanded Choledochal cysts type I and II 
hi1532B foie gras foie gras (fgr) Conserved in metazoa; novel Large Wild type Steatosis 
hi3237 thoc2 thoc2 Conserved to yeast; couples mitotic recombination, transcription and RNA export Large Wild type None observed 
hi3785 γ-tubulin γ-tub Conserved to yeast; centrosome protein Large Wild type None observed 
hi1134 sox9a jelly fish (jef) Conserved in metazoa; tissue specific transcription factor Wild type Wild type None observed 
hi1858A paté paté (pté) Conserved to yeast; novel Wild type Wild type None observed 

The cellular phenotype and deduced hepatic pathology is indicated.

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