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Table 1.

The Rab family

Rab Localization Function References
(1) Rab23 Rab23
 
Plasma membrane and endosomes
 
Trafficking of sonic hedgehog signaling components; embryogenesis; ciliary trafficking
 
Evans et al., 2003 
 
(2) Rab29, Rab32, Rab38, Rab7L1
 
   
Rab32   Perinuclear vesicles; mitochondria   Post-Golgi trafficking of melanogenic enzymes; binds PKA and regulates mitochondrial dynamics  Alto et al., 2002; Wasmeier et al., 2006  
Rab38
 
Tyrosinase-positive vesicles
 
Post-Golgi biogenesis of melanosomes
 
Wasmeier et al., 2006 
 
(3) RabL2, RabL3, RabL5
 
   
(4) Ran
 

 

 

 
Ran
 
Nucleus, cytoplasm
 
Nucleocytoplasmic transport
 
Joseph, 2006 
 
(5) Rab7, Rab7b, Rab9
 
   
Rab7, Rab7b   Late endosomes, lysosomes   Transport from early to late endosomes; lysosome biogenesis; b) transport to lysosomes, TLR4 signaling  Feng et al., 2001; Bucci et al., 2000; Wang et al., 2007  
Rab9a,b,c
 
Late endosomes
 
Lysosomal enzyme and cholesterol trafficking; late endosome to trans-Golgi transport
 
Ganley et al., 2004; Lombardi et al., 1993; Narita et al., 2005 
 
(6) Rab28, RabL4
 
   
(7) Rab34, Rab36
 
   
Rab34
 
Cell surface membrane ruffles, lysosomes
 
Regulation of spatial distribution of lysosomes; Formation of macropinosomes
 
Colucci et al., 2005; Sun and Endo, 2005; Sun et al., 2003; Wu et al., 2005 
 
(8) Rab6, Rab41
 
   
Rab6a,a′,b,c
 
(a,a′,b) Golgi, (b) ERGIC-53-positive vesicles and neuronal cell specific
 
Retrograde transport; (a,b) Golgi to ER and intra-Golgi tranport, Golgi stress response (a′) endosome to Golgi transport; (c) multi-drug resistance regulation
 
Jiang and Storrie, 2005; Martinez et al., 1994; Del Nery et al., 2006; Opdam et al., 2000; Shan et al., 2000 
 
(9) Rab5, Rab17, Rab20, Rab21, Rab22a/Rab31, Rab24
 
   
Rab5a,b,c   Clathrin coated vesicles, caveosomes, and early endosomes.   Endocytosis, early endosome fusion, caveolar vesicle targeting to early endosomes; (a) EGF receptor activation; (b) neuroprotection  Pelkmans et al., 2004; Barbieri et al., 2000; Arnett et al., 2004; Bucci et al., 1995  
Rab17   Epithelial specific; apical recycling endosome   Transport through apical recycling endosomes; polarized sorting  Zacchi et al., 1998  
Rab20   Epithelial specific; kidney dense apical tubules   V-ATPase trafficking  Curtis and Gluck, 2005  
Rab21   Early endosomes   Endocytosis of integrins, cell-extracellular matrix adhesion and motility  Pellinen et al., 2006  
Rab22a,b,c/Rab31   Early endosomes and trans-Golgi   Biosynthetic pathway; (a) endosome to Golgi transport; phagosome maturation (b) trans-Golgi to endosome transport  Kauppi et al., 2002; Mesa et al., 2001; Roberts et al., 2006; Rodriguez-Gabin et al., 2001  
Rab24
 
Autophagosomes, nuclear inclusions
 
Induction of autophagy, tyrosine phosphorylated
 
Munafó and Colombo, 2002; Overmeyer and Maltese, 2005 
 
(10) Rab18
 
   
Rab18
 
Dense apical tubules (kidney) and basolateral membrane (intestine); ER/lipid droplets; neuroendocrine secretory granules
 
Formation of lipid droplets from ER; negative regulator of neuroendocrine secretion
 
Lütcke et al., 1994; Ozeki et al., 2005; Vazquez-Martinez et al., 2007 
 
(11) Rab2, Rab4, Rab11, Rab14, Rab25, Rab39, Rab42
 
   
Rab2a,b   Endoplasmic reticulum   ER to Golgi transport  Tisdale et al., 1992  
Rab4a,b,c   Early and recycling endosomes   Rapid endocytic recycling to plasma membrane; (a) adherens junction disassembly  van der Sluijs et al., 1992; Mruk et al., 2007; Bottger et al., 1996  
Rab11a,b   (a) Golgi and recycling endosomes; (b) neuronal specific   (a) Transport from Golgi to apical endocytic recycling endosomes; phagocytosis in macrophages; (b) Ca2+-dependent secretion  Ullrich et al., 1996; Wilcke et al., 2000; Khvotchev et al., 2003  
Rab14   Rough ER; Golgi/trans-Golgi and early endosomes   Phagosome and early endosome fusion; trafficking between early endosomes and Golgi  Junutula et al., 2004; Kyei et al., 2006; Proikas-Cezanne et al., 2006  
Rab25   Epithelial specific; apical recycling endosome   Transport of apical recycling endosomes  Casanova et al., 1999; Wang et al., 2000  
(12) Rab19, Rab30, Rab33, Rab43
 
   
Rab33a,b
 
Medial Golgi
 
Retrograde Golgi transport to ER
 
Valsdottir et al., 2001 
 
(13) Rab1, Rab3, Rab8, Rab10, Rab12, Rab13, Rab15, Rab40
 
   
Rab1a,b   Endoplasmic reticulum   ER to Golgi transport  Tisdale et al., 1992; Allan et al., 2000  
Rab3a,b,c,d   Synaptic and secretory vesicles.   Regulated exocytosis; (a-d) Ca2+-dependent secretion and vesicle docking; dense-core vesicle docking to the plasma membrane (with Rab27)  Rupnik et al., 2007; Schlüter et al., 2002; Tsuboi and Fukuda, 2006  
Rab8a,b   Golgi region, endosomes, dendrites, basolateral plasma membrane   Trafficking between Golgi, endosomes and plasma membrane; cholesterol degradation; Extension of primary ciliary membrane (a) basolateral transport in epithelia and dendritic transport in neurons; (b) adherens junction assembly  Nachury et al., 2007; Peränen et al., 1996; Chen et al., 2001; Chen and Wandinger-Ness, 2001; Hattula et al., 2006; Linder et al., 2007  
Rab10   Golgi   Polarized membrane transport from Golgi to basolateral membrane, may co-operate with Rab8  Babbey et al., 2006; Chen et al., 1993; Schuck et al., 2007  
Rab12   Centrosomes   Transport from cell periphery to perinuclear centrosomes  Iida et al., 2005  
Rab13   Tight junctions and endosomes   Tight junction biogenesis  Marzesco et al., 2002  
Rab15
 
Early/sorting and recycling endosomes
 
Trafficking through recycling endosomes; coordinates rapid and slow recycling; attenuates Rab5 function
 
Elferink and Strick, 2005; Zuk and Elferink, 2000 
 
(14) Rab26, Rab27, Rab37, Rab44, Rasef
 
   
Rab26   Secretory granules   Regulated secretion of granules  Yoshie et al., 2000  
Rab27a,b   Epithelial specific; melanosomes   Exocytosis; (a) Transport of secretory granules, dense-core vesicles (with Rab3a) and lysosome-related organelles; myosin recruitment to melanosomes; (b) platelet specific, regulated secretion  Barral et al., 2002; Futter, 2006; Tolmachova et al., 2007; Tsuboi and Fukuda, 2006  
Rab37   Secretory granules (insulin and mast cell granules)   Mast cell degranulation  Masuda et al., 2000; Brunner et al., 2007  
Rab Localization Function References
(1) Rab23 Rab23
 
Plasma membrane and endosomes
 
Trafficking of sonic hedgehog signaling components; embryogenesis; ciliary trafficking
 
Evans et al., 2003 
 
(2) Rab29, Rab32, Rab38, Rab7L1
 
   
Rab32   Perinuclear vesicles; mitochondria   Post-Golgi trafficking of melanogenic enzymes; binds PKA and regulates mitochondrial dynamics  Alto et al., 2002; Wasmeier et al., 2006  
Rab38
 
Tyrosinase-positive vesicles
 
Post-Golgi biogenesis of melanosomes
 
Wasmeier et al., 2006 
 
(3) RabL2, RabL3, RabL5
 
   
(4) Ran
 

 

 

 
Ran
 
Nucleus, cytoplasm
 
Nucleocytoplasmic transport
 
Joseph, 2006 
 
(5) Rab7, Rab7b, Rab9
 
   
Rab7, Rab7b   Late endosomes, lysosomes   Transport from early to late endosomes; lysosome biogenesis; b) transport to lysosomes, TLR4 signaling  Feng et al., 2001; Bucci et al., 2000; Wang et al., 2007  
Rab9a,b,c
 
Late endosomes
 
Lysosomal enzyme and cholesterol trafficking; late endosome to trans-Golgi transport
 
Ganley et al., 2004; Lombardi et al., 1993; Narita et al., 2005 
 
(6) Rab28, RabL4
 
   
(7) Rab34, Rab36
 
   
Rab34
 
Cell surface membrane ruffles, lysosomes
 
Regulation of spatial distribution of lysosomes; Formation of macropinosomes
 
Colucci et al., 2005; Sun and Endo, 2005; Sun et al., 2003; Wu et al., 2005 
 
(8) Rab6, Rab41
 
   
Rab6a,a′,b,c
 
(a,a′,b) Golgi, (b) ERGIC-53-positive vesicles and neuronal cell specific
 
Retrograde transport; (a,b) Golgi to ER and intra-Golgi tranport, Golgi stress response (a′) endosome to Golgi transport; (c) multi-drug resistance regulation
 
Jiang and Storrie, 2005; Martinez et al., 1994; Del Nery et al., 2006; Opdam et al., 2000; Shan et al., 2000 
 
(9) Rab5, Rab17, Rab20, Rab21, Rab22a/Rab31, Rab24
 
   
Rab5a,b,c   Clathrin coated vesicles, caveosomes, and early endosomes.   Endocytosis, early endosome fusion, caveolar vesicle targeting to early endosomes; (a) EGF receptor activation; (b) neuroprotection  Pelkmans et al., 2004; Barbieri et al., 2000; Arnett et al., 2004; Bucci et al., 1995  
Rab17   Epithelial specific; apical recycling endosome   Transport through apical recycling endosomes; polarized sorting  Zacchi et al., 1998  
Rab20   Epithelial specific; kidney dense apical tubules   V-ATPase trafficking  Curtis and Gluck, 2005  
Rab21   Early endosomes   Endocytosis of integrins, cell-extracellular matrix adhesion and motility  Pellinen et al., 2006  
Rab22a,b,c/Rab31   Early endosomes and trans-Golgi   Biosynthetic pathway; (a) endosome to Golgi transport; phagosome maturation (b) trans-Golgi to endosome transport  Kauppi et al., 2002; Mesa et al., 2001; Roberts et al., 2006; Rodriguez-Gabin et al., 2001  
Rab24
 
Autophagosomes, nuclear inclusions
 
Induction of autophagy, tyrosine phosphorylated
 
Munafó and Colombo, 2002; Overmeyer and Maltese, 2005 
 
(10) Rab18
 
   
Rab18
 
Dense apical tubules (kidney) and basolateral membrane (intestine); ER/lipid droplets; neuroendocrine secretory granules
 
Formation of lipid droplets from ER; negative regulator of neuroendocrine secretion
 
Lütcke et al., 1994; Ozeki et al., 2005; Vazquez-Martinez et al., 2007 
 
(11) Rab2, Rab4, Rab11, Rab14, Rab25, Rab39, Rab42
 
   
Rab2a,b   Endoplasmic reticulum   ER to Golgi transport  Tisdale et al., 1992  
Rab4a,b,c   Early and recycling endosomes   Rapid endocytic recycling to plasma membrane; (a) adherens junction disassembly  van der Sluijs et al., 1992; Mruk et al., 2007; Bottger et al., 1996  
Rab11a,b   (a) Golgi and recycling endosomes; (b) neuronal specific   (a) Transport from Golgi to apical endocytic recycling endosomes; phagocytosis in macrophages; (b) Ca2+-dependent secretion  Ullrich et al., 1996; Wilcke et al., 2000; Khvotchev et al., 2003  
Rab14   Rough ER; Golgi/trans-Golgi and early endosomes   Phagosome and early endosome fusion; trafficking between early endosomes and Golgi  Junutula et al., 2004; Kyei et al., 2006; Proikas-Cezanne et al., 2006  
Rab25   Epithelial specific; apical recycling endosome   Transport of apical recycling endosomes  Casanova et al., 1999; Wang et al., 2000  
(12) Rab19, Rab30, Rab33, Rab43
 
   
Rab33a,b
 
Medial Golgi
 
Retrograde Golgi transport to ER
 
Valsdottir et al., 2001 
 
(13) Rab1, Rab3, Rab8, Rab10, Rab12, Rab13, Rab15, Rab40
 
   
Rab1a,b   Endoplasmic reticulum   ER to Golgi transport  Tisdale et al., 1992; Allan et al., 2000  
Rab3a,b,c,d   Synaptic and secretory vesicles.   Regulated exocytosis; (a-d) Ca2+-dependent secretion and vesicle docking; dense-core vesicle docking to the plasma membrane (with Rab27)  Rupnik et al., 2007; Schlüter et al., 2002; Tsuboi and Fukuda, 2006  
Rab8a,b   Golgi region, endosomes, dendrites, basolateral plasma membrane   Trafficking between Golgi, endosomes and plasma membrane; cholesterol degradation; Extension of primary ciliary membrane (a) basolateral transport in epithelia and dendritic transport in neurons; (b) adherens junction assembly  Nachury et al., 2007; Peränen et al., 1996; Chen et al., 2001; Chen and Wandinger-Ness, 2001; Hattula et al., 2006; Linder et al., 2007  
Rab10   Golgi   Polarized membrane transport from Golgi to basolateral membrane, may co-operate with Rab8  Babbey et al., 2006; Chen et al., 1993; Schuck et al., 2007  
Rab12   Centrosomes   Transport from cell periphery to perinuclear centrosomes  Iida et al., 2005  
Rab13   Tight junctions and endosomes   Tight junction biogenesis  Marzesco et al., 2002  
Rab15
 
Early/sorting and recycling endosomes
 
Trafficking through recycling endosomes; coordinates rapid and slow recycling; attenuates Rab5 function
 
Elferink and Strick, 2005; Zuk and Elferink, 2000 
 
(14) Rab26, Rab27, Rab37, Rab44, Rasef
 
   
Rab26   Secretory granules   Regulated secretion of granules  Yoshie et al., 2000  
Rab27a,b   Epithelial specific; melanosomes   Exocytosis; (a) Transport of secretory granules, dense-core vesicles (with Rab3a) and lysosome-related organelles; myosin recruitment to melanosomes; (b) platelet specific, regulated secretion  Barral et al., 2002; Futter, 2006; Tolmachova et al., 2007; Tsuboi and Fukuda, 2006  
Rab37   Secretory granules (insulin and mast cell granules)   Mast cell degranulation  Masuda et al., 2000; Brunner et al., 2007  

Uncharacterized Rab family members are highlighted in red.

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