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Table 6.

Inactivation of ATP2C1 changes baseline Ca²⁺ and Ca²⁺ signaling

	Control keratinocytes					DD keratinocytes
	Transfection control	siRNA-treated for 72 hours	P value	Transfection control	siRNA-treated for 48 hours	P value
Baseline 0.06 mM Ca²⁺ (nM)	70.30±15.69 (n=20)	102.19±17.89 (n=16)	<0.001	34.58±11.85 (n=17)	48.94±16.72 (n=17)	<0.01
1.0 mM Ca²⁺ (nM)	144.53±27.43 (n=20)	125.87±22.12 (n=16)	0.030	91.67±22.75 (n=13)	59.82±19.23 (n=17)	<0.001
Fold increase	2.08±0.54 (n=20)	1.21±0.18 (n=16)	<0.0001	3.05±1.15 (n=13)	1.25±0.26 (n=17)	<0.0001

	Control keratinocytes					DD keratinocytes
	Transfection control	siRNA-treated for 72 hours	P value	Transfection control	siRNA-treated for 48 hours	P value
Baseline 0.06 mM Ca²⁺ (nM)	70.30±15.69 (n=20)	102.19±17.89 (n=16)	<0.001	34.58±11.85 (n=17)	48.94±16.72 (n=17)	<0.01
1.0 mM Ca²⁺ (nM)	144.53±27.43 (n=20)	125.87±22.12 (n=16)	0.030	91.67±22.75 (n=13)	59.82±19.23 (n=17)	<0.001
Fold increase	2.08±0.54 (n=20)	1.21±0.18 (n=16)	<0.0001	3.05±1.15 (n=13)	1.25±0.26 (n=17)	<0.0001