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Table 1.

Properties of Xin and XIRP2 polypeptides

Xin/XIRP2 peptide Actin-binding capacity Low-speed co-sedimentation Targeting to stress fibres Targeting to focal adhesions
XR3-4 (Xin 146-205)   -   -   -   (—)*  
XR10-11 (Xin 432-536)   -   -   -   (—)*  
XR1-3 (Xin 83-173)   +/-   +/-   +   (—)*  
XR4-6 (Xin 179-324)   +/-   n.d.   +   (—)*  
XR1-4 (Xin 83-205)   +/-   +/-   +   (—)*  
XR1-5 (Xin 83-247)   +/-   +/-   +   (—)*  
XR1-6 (Xin 83-324)   +   +   +   +  
XR6-11 (Xin 259-526)   +   +   n.d.   n.d.  
XR11-16 (Xin 502-749)   +   n.d.   n.d.   n.d.  
XR1-11 (Xin 83-526)   ++   ++   +   +  
XR1-16 (Xin 83-749)   ++   ++   +   +  
Xin FL (Xin 1-1121)   n.d.   n.d.   +   +  
XIRP2 (repeats 1-28)   +   +   +   +  
Xin/XIRP2 peptide Actin-binding capacity Low-speed co-sedimentation Targeting to stress fibres Targeting to focal adhesions
XR3-4 (Xin 146-205)   -   -   -   (—)*  
XR10-11 (Xin 432-536)   -   -   -   (—)*  
XR1-3 (Xin 83-173)   +/-   +/-   +   (—)*  
XR4-6 (Xin 179-324)   +/-   n.d.   +   (—)*  
XR1-4 (Xin 83-205)   +/-   +/-   +   (—)*  
XR1-5 (Xin 83-247)   +/-   +/-   +   (—)*  
XR1-6 (Xin 83-324)   +   +   +   +  
XR6-11 (Xin 259-526)   +   +   n.d.   n.d.  
XR11-16 (Xin 502-749)   +   n.d.   n.d.   n.d.  
XR1-11 (Xin 83-526)   ++   ++   +   +  
XR1-16 (Xin 83-749)   ++   ++   +   +  
Xin FL (Xin 1-1121)   n.d.   n.d.   +   +  
XIRP2 (repeats 1-28)   +   +   +   +  

-, no detectable binding capacity or targeting; (—)*, essentially negative targeting; +/-, weak binding capacity; +, high binding capacity or strong targeting; ++, very high binding capacity; n.d., not determined; FL, full length.

Peptide name is given with the corresponding residues of the full-length protein in parentheses.

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