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Table 1.

Cell adhesion and spreading on different substrata geometries

Spacing between dots (μm)
Dot size (μm2) 1 2 5 10 15 20 25 30
0.1   A, S   A, S   a, ns   na, ns      
0.25    A, S   a, s   a, ns      
1     A, S   a, s   a, s   a, s    
9      A, S   A, S   a, s   a, s   a, ns  
Spacing between dots (μm)
Dot size (μm2) 1 2 5 10 15 20 25 30
0.1   A, S   A, S   a, ns   na, ns      
0.25    A, S   a, s   a, ns      
1     A, S   a, s   a, s   a, s    
9      A, S   A, S   a, s   a, s   a, ns  

Cells were cultured for 1 hour on patterned substrata and labelled for actin. The number of adhering cells (B16, 3T3 and BRL) and their spreading areas (B16, 3T3) were analysed.

A, number of adhering cells similar to that on homogenous substrata; a, number of adhering cells smaller than on homogenous substrata; na, no adhesion; S, spreading area 50% or larger than on homogenous substrata; s, spreading area less than 50% of that on homogenous substrata; ns, spreading area as on uncoated substrata.

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