Table 1.

Summary of functional information for actin subfamilies

Actin subfamilyOrganisms?LocalizationEssential In yeast?Function
Actin Human→Giardia (Ubiquitous?) CytoplasmMFY, nucleusM Cell motility/transportMFY, polarityMFY, chromatin remodelingMY 
Arp1 Human→yeast CytoplasmMFY N (spindle alignment) Dynein motor function (dynactin complexMFY
Arp2 Human→yeast, Arabidopsis CytoplasmMFY Actin polymerization (Arp2/3 complexMFY
Arp3 Human→yeast, Arabidopsis CytoplasmMFY Actin polymerization (Arp2/3 complexMFY
Arp4 Human→yeast, Arabidopsis NucleusY Chromatin remodeling (SWI/SNFM, INO80Y,NuA4Y, histone acetyltransferaseYM
Arp5 Human→yeast, Arabidopsis NucleusY Chromatin remodeling (INO80 complexY
Arp6 Human→yeast, Arabidopsis NucleusFY Localized to heterochromatinF 
Arp8 Human→yeast, Arabidopsis NucleusY Chromatin remodeling (INO80 complexY
Arp10 Likely human→yeast CytoplasmMY Dynein motor function (dynactin complexM, N. crassa
Orphans     
Arps 7,9 S. cerevisiae, S. pombe (Arp 9) NucleusY Y/Y Chromatin remodeling (SWI/SNFY, RSC complexY
Actin subfamilyOrganisms?LocalizationEssential In yeast?Function
Actin Human→Giardia (Ubiquitous?) CytoplasmMFY, nucleusM Cell motility/transportMFY, polarityMFY, chromatin remodelingMY 
Arp1 Human→yeast CytoplasmMFY N (spindle alignment) Dynein motor function (dynactin complexMFY
Arp2 Human→yeast, Arabidopsis CytoplasmMFY Actin polymerization (Arp2/3 complexMFY
Arp3 Human→yeast, Arabidopsis CytoplasmMFY Actin polymerization (Arp2/3 complexMFY
Arp4 Human→yeast, Arabidopsis NucleusY Chromatin remodeling (SWI/SNFM, INO80Y,NuA4Y, histone acetyltransferaseYM
Arp5 Human→yeast, Arabidopsis NucleusY Chromatin remodeling (INO80 complexY
Arp6 Human→yeast, Arabidopsis NucleusFY Localized to heterochromatinF 
Arp8 Human→yeast, Arabidopsis NucleusY Chromatin remodeling (INO80 complexY
Arp10 Likely human→yeast CytoplasmMY Dynein motor function (dynactin complexM, N. crassa
Orphans     
Arps 7,9 S. cerevisiae, S. pombe (Arp 9) NucleusY Y/Y Chromatin remodeling (SWI/SNFY, RSC complexY

Superscripts (M,F,Y) refer to the type of organism (mammal, fly,yeast) in which the observation was made. The ARP10 subfamily is italicized to indicate that bootstrap confidence in the validity of the observed grouping is low. However, the observations that mammalian Arp11 is part of dynactin and that Neurospora RO7 protein is required for proper localization and function of dynein (Lee et al.,2001) support the existence of a conserved subfamily.

Yeast localization and deletion phenotype data are summarized byHarata et al., 2000 and the Saccharomyces Genome Database(http://genome-www.stanford.edu/Saccharomyces). No Arp10 deletions have been reported in the literature. Characterization of biochemical associations of conventional actin, ScARP4, ScARP5, ScARP5,ScARP7/9 and HsBAF53 with transcription machinery can be found inCairns et al., 1998;Galarneau et al., 2000;Harata et al., 1999;Park et al., 2002;Peterson et al., 1998;Zhao et al., 1998;Shen et al., 2000. Other primary references for characterization of actin, Arp1, Arp2, Arp3 and individual Arp subfamily members can be found referenced inMachesky and May, 2001;Schafer and Schroer, 1999. Our apologies to those authors we were not able to cite due to space restrictions.

Close Modal

or Create an Account

Close Modal
Close Modal