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Table 6.

Effect of T3 or GC-1 treatment of hypothyroid rats on parameters characterizing the response to oxidative stress of tissue homogenates

TissueParameterCHH+T3H+GC-1
Liver a 77.4±3.6 69.0±5.2 108.8±4.8a,b 83.9±4.7c 
 b 1.57±0.10 1.45±0.11 1.17±0.09a 1.25±0.05a 
 Emax 18.1±0.9 17.4±1.2 34.2±2.7a,b 24.2±2.1a,b,c 
Heart a 141.3±4.3 121.7±9.1 169.5±10.4a,b 130.8±10.0c 
 b 0.27±0.04 0.25±0.01 0.21±0.02 0.23±0.01 
 Emax 192.4±20.2 186.1±14.1 283.3±24.1a,b 209.1±19.7c 
Muscle a 51.6±1.2 44.7±3.2 57.6±4.0b 49.8±3.1 
 b 0.29±0.03 0.23±0.02 0.19±0.02a 0.20±0.01a 
 Emax 65.4±5.8 71.4±6.1 109.5±7.5a,b 91.5±6.3a,b 
TissueParameterCHH+T3H+GC-1
Liver a 77.4±3.6 69.0±5.2 108.8±4.8a,b 83.9±4.7c 
 b 1.57±0.10 1.45±0.11 1.17±0.09a 1.25±0.05a 
 Emax 18.1±0.9 17.4±1.2 34.2±2.7a,b 24.2±2.1a,b,c 
Heart a 141.3±4.3 121.7±9.1 169.5±10.4a,b 130.8±10.0c 
 b 0.27±0.04 0.25±0.01 0.21±0.02 0.23±0.01 
 Emax 192.4±20.2 186.1±14.1 283.3±24.1a,b 209.1±19.7c 
Muscle a 51.6±1.2 44.7±3.2 57.6±4.0b 49.8±3.1 
 b 0.29±0.03 0.23±0.02 0.19±0.02a 0.20±0.01a 
 Emax 65.4±5.8 71.4±6.1 109.5±7.5a,b 91.5±6.3a,b 

Values are means ± s.e.m. of eight experiments. The relationship between light emission (E) and homogenate concentration of mitochondria (C) is described by the equation: E=aC/exp(bC), where a, b and e are constants. Emax=a/eb. For explanation see text

C, control euthyroid rats; H, hypothyroid rats; H+T3,hypothyroid T3-treated rats; H+GC-1, hypothyroid GC-1-treated rats

a

Significant vs C rats

b

significant vs H rats

c

significant vs H+T3 rats. The level of significance was chosen as P<0.05

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