Effect of T3 or GC-1 treatment of hypothyroid rats on parameters characterizing the response to oxidative stress of tissue homogenates
| Tissue . | Parameter . | C . | H . | H+T3 . | H+GC-1 . |
|---|---|---|---|---|---|
| Liver | a | 77.4±3.6 | 69.0±5.2 | 108.8±4.8a,b | 83.9±4.7c |
| b | 1.57±0.10 | 1.45±0.11 | 1.17±0.09a | 1.25±0.05a | |
| Emax | 18.1±0.9 | 17.4±1.2 | 34.2±2.7a,b | 24.2±2.1a,b,c | |
| Heart | a | 141.3±4.3 | 121.7±9.1 | 169.5±10.4a,b | 130.8±10.0c |
| b | 0.27±0.04 | 0.25±0.01 | 0.21±0.02 | 0.23±0.01 | |
| Emax | 192.4±20.2 | 186.1±14.1 | 283.3±24.1a,b | 209.1±19.7c | |
| Muscle | a | 51.6±1.2 | 44.7±3.2 | 57.6±4.0b | 49.8±3.1 |
| b | 0.29±0.03 | 0.23±0.02 | 0.19±0.02a | 0.20±0.01a | |
| Emax | 65.4±5.8 | 71.4±6.1 | 109.5±7.5a,b | 91.5±6.3a,b |
| Tissue . | Parameter . | C . | H . | H+T3 . | H+GC-1 . |
|---|---|---|---|---|---|
| Liver | a | 77.4±3.6 | 69.0±5.2 | 108.8±4.8a,b | 83.9±4.7c |
| b | 1.57±0.10 | 1.45±0.11 | 1.17±0.09a | 1.25±0.05a | |
| Emax | 18.1±0.9 | 17.4±1.2 | 34.2±2.7a,b | 24.2±2.1a,b,c | |
| Heart | a | 141.3±4.3 | 121.7±9.1 | 169.5±10.4a,b | 130.8±10.0c |
| b | 0.27±0.04 | 0.25±0.01 | 0.21±0.02 | 0.23±0.01 | |
| Emax | 192.4±20.2 | 186.1±14.1 | 283.3±24.1a,b | 209.1±19.7c | |
| Muscle | a | 51.6±1.2 | 44.7±3.2 | 57.6±4.0b | 49.8±3.1 |
| b | 0.29±0.03 | 0.23±0.02 | 0.19±0.02a | 0.20±0.01a | |
| Emax | 65.4±5.8 | 71.4±6.1 | 109.5±7.5a,b | 91.5±6.3a,b |
Values are means ± s.e.m. of eight experiments. The relationship between light emission (E) and homogenate concentration of mitochondria (C) is described by the equation: E=aC/exp(bC), where a, b and e are constants. Emax=a/eb. For explanation see text
C, control euthyroid rats; H, hypothyroid rats; H+T3,hypothyroid T3-treated rats; H+GC-1, hypothyroid GC-1-treated rats
Significant vs C rats
significant vs H rats
significant vs H+T3 rats. The level of significance was chosen as P<0.05