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Table 5.

Effect of T3 or GC-1 treatment of hypothyroid rats on tissue antioxidants

TissueParameterCHH+T3H+GC-1
Liver GPX 68.7±1.5 74.5±2.9 82.5±3.9a 82.8±1.4a 
 GR 10.1±0.3 9.6±0.2a 13.7±0.7a,b 9.9±0.2c 
 Vit E 31.9±1.0 22.0±0.8a 38.5±2.6a,b 30.4±1.2b,c 
 CoQ9 68.3±2.6 62.8±2.4 87.3±2.0a,b 78.1±1.9a,b,c 
 CoQ10 6.1±0.5 6.5±0.4 8.6±0.2a,b 7.8±0.2a,b 
 GSH 5.16±0.09 5.58±0.13a 3.78±0.09a,b 4.68±0.22a,b,c 
Heart GPX 8.6±0.3 5.8±0.4a 8.1±0.3b 8.4±0.2b 
 GR 1.1±0.1 0.8±0.1a 1.3±0.1b 1.2±0.1b 
 Vit E 31.5±0.4 22.4±0.8a 42.0±1.4a,b 36.2±1.2a,b,c 
 CoQ9 79.9±6.1 83.8±3.7 127.3±1.7a,b 108.7±2.0a,b,c 
 CoQ10 5.7±0.5 6.7±0.4 10.4±0.5a,b 8.7±0.3a,b,c 
 GSH 1.59±0.11 1.33±0.03a 0.93±0.02a,b 1.28±0.03a,c 
Muscle GPX 2.6±0.1 2.3±0.2 2.8±0.2 2.5±0.1 
 GR 0.67±0.04 0.61±0.03 0.81±0.05b 0.76±0.04b 
 Vit E 12.7±0.3 10.0±0.7a 18.8±0.8a,b 14.3±0.7b,c 
 CoQ9 36.4±0.8 34.8±0.6 46.9±1.6a,b 41.1±0.6a,b,c 
 CoQ10 2.9±0.2 3.0±0.1 3.7±0.2a,b 3.6±0.2a,b 
 GSH 1.36±0.09 1.10±0.03a 0.90±0.03a,b 1.11±0.03a,c 
TissueParameterCHH+T3H+GC-1
Liver GPX 68.7±1.5 74.5±2.9 82.5±3.9a 82.8±1.4a 
 GR 10.1±0.3 9.6±0.2a 13.7±0.7a,b 9.9±0.2c 
 Vit E 31.9±1.0 22.0±0.8a 38.5±2.6a,b 30.4±1.2b,c 
 CoQ9 68.3±2.6 62.8±2.4 87.3±2.0a,b 78.1±1.9a,b,c 
 CoQ10 6.1±0.5 6.5±0.4 8.6±0.2a,b 7.8±0.2a,b 
 GSH 5.16±0.09 5.58±0.13a 3.78±0.09a,b 4.68±0.22a,b,c 
Heart GPX 8.6±0.3 5.8±0.4a 8.1±0.3b 8.4±0.2b 
 GR 1.1±0.1 0.8±0.1a 1.3±0.1b 1.2±0.1b 
 Vit E 31.5±0.4 22.4±0.8a 42.0±1.4a,b 36.2±1.2a,b,c 
 CoQ9 79.9±6.1 83.8±3.7 127.3±1.7a,b 108.7±2.0a,b,c 
 CoQ10 5.7±0.5 6.7±0.4 10.4±0.5a,b 8.7±0.3a,b,c 
 GSH 1.59±0.11 1.33±0.03a 0.93±0.02a,b 1.28±0.03a,c 
Muscle GPX 2.6±0.1 2.3±0.2 2.8±0.2 2.5±0.1 
 GR 0.67±0.04 0.61±0.03 0.81±0.05b 0.76±0.04b 
 Vit E 12.7±0.3 10.0±0.7a 18.8±0.8a,b 14.3±0.7b,c 
 CoQ9 36.4±0.8 34.8±0.6 46.9±1.6a,b 41.1±0.6a,b,c 
 CoQ10 2.9±0.2 3.0±0.1 3.7±0.2a,b 3.6±0.2a,b 
 GSH 1.36±0.09 1.10±0.03a 0.90±0.03a,b 1.11±0.03a,c 

Values are means ± s.e.m. For each value eight rats were used. Glutathione peroxidase activity (GPX) is expressed in μmol NADPH min–1 g–1 tissue. Glutathione reductase (GR)is expressed in μmol NADPH min–1 g–1tissue. Vitamin E (Vit E), coenzyme Q9 (CoQ9) and coenzyme Q10 (CoQ10) content is expressed in nmol g–1 tissue. Reduced glutathione (GSH) is expressed in μmol g–1 tissue

C, control euthyroid rats; H, hypothyroid rats; H+T3,hypothyroid T3-treated rats; H+GC-1, hypothyroid GC-1-treated rats

a

Significant vs C rats

b

significant vs H rats

c

significant vs H+T3 rats. The level of significance was chosen as P<0.05

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