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Table 5.

Effect of T₃ or GC-1 treatment of hypothyroid rats on tissue antioxidants

Tissue	Parameter	C	H	H+T₃	H+GC-1
Liver	GPX	68.7±1.5	74.5±2.9	82.5±3.9^{^a}	82.8±1.4^{^a}
	GR	10.1±0.3	9.6±0.2^{^a}	13.7±0.7^{^a}^,^{^b}	9.9±0.2^{^c}
	Vit E	31.9±1.0	22.0±0.8^{^a}	38.5±2.6^{^a}^,^{^b}	30.4±1.2^{^b}^,^{^c}
	CoQ9	68.3±2.6	62.8±2.4	87.3±2.0^{^a}^,^{^b}	78.1±1.9^{^a}^,^{^b}^,^{^c}
	CoQ10	6.1±0.5	6.5±0.4	8.6±0.2^{^a}^,^{^b}	7.8±0.2^{^a}^,^{^b}
	GSH	5.16±0.09	5.58±0.13^{^a}	3.78±0.09^{^a}^,^{^b}	4.68±0.22^{^a}^,^{^b}^,^{^c}
Heart	GPX	8.6±0.3	5.8±0.4^{^a}	8.1±0.3^{^b}	8.4±0.2^{^b}
	GR	1.1±0.1	0.8±0.1^{^a}	1.3±0.1^{^b}	1.2±0.1^{^b}
	Vit E	31.5±0.4	22.4±0.8^{^a}	42.0±1.4^{^a}^,^{^b}	36.2±1.2^{^a}^,^{^b}^,^{^c}
	CoQ9	79.9±6.1	83.8±3.7	127.3±1.7^{^a}^,^{^b}	108.7±2.0^{^a}^,^{^b}^,^{^c}
	CoQ10	5.7±0.5	6.7±0.4	10.4±0.5^{^a}^,^{^b}	8.7±0.3^{^a}^,^{^b}^,^{^c}
	GSH	1.59±0.11	1.33±0.03^{^a}	0.93±0.02^{^a}^,^{^b}	1.28±0.03^{^a}^,^{^c}
Muscle	GPX	2.6±0.1	2.3±0.2	2.8±0.2	2.5±0.1
	GR	0.67±0.04	0.61±0.03	0.81±0.05^{^b}	0.76±0.04^{^b}
	Vit E	12.7±0.3	10.0±0.7^{^a}	18.8±0.8^{^a}^,^{^b}	14.3±0.7^{^b}^,^{^c}
	CoQ9	36.4±0.8	34.8±0.6	46.9±1.6^{^a}^,^{^b}	41.1±0.6^{^a}^,^{^b}^,^{^c}
	CoQ10	2.9±0.2	3.0±0.1	3.7±0.2^{^a}^,^{^b}	3.6±0.2^{^a}^,^{^b}
	GSH	1.36±0.09	1.10±0.03^{^a}	0.90±0.03^{^a}^,^{^b}	1.11±0.03^{^a}^,^{^c}

Tissue	Parameter	C	H	H+T₃	H+GC-1
Liver	GPX	68.7±1.5	74.5±2.9	82.5±3.9^{^a}	82.8±1.4^{^a}
	GR	10.1±0.3	9.6±0.2^{^a}	13.7±0.7^{^a}^,^{^b}	9.9±0.2^{^c}
	Vit E	31.9±1.0	22.0±0.8^{^a}	38.5±2.6^{^a}^,^{^b}	30.4±1.2^{^b}^,^{^c}
	CoQ9	68.3±2.6	62.8±2.4	87.3±2.0^{^a}^,^{^b}	78.1±1.9^{^a}^,^{^b}^,^{^c}
	CoQ10	6.1±0.5	6.5±0.4	8.6±0.2^{^a}^,^{^b}	7.8±0.2^{^a}^,^{^b}
	GSH	5.16±0.09	5.58±0.13^{^a}	3.78±0.09^{^a}^,^{^b}	4.68±0.22^{^a}^,^{^b}^,^{^c}
Heart	GPX	8.6±0.3	5.8±0.4^{^a}	8.1±0.3^{^b}	8.4±0.2^{^b}
	GR	1.1±0.1	0.8±0.1^{^a}	1.3±0.1^{^b}	1.2±0.1^{^b}
	Vit E	31.5±0.4	22.4±0.8^{^a}	42.0±1.4^{^a}^,^{^b}	36.2±1.2^{^a}^,^{^b}^,^{^c}
	CoQ9	79.9±6.1	83.8±3.7	127.3±1.7^{^a}^,^{^b}	108.7±2.0^{^a}^,^{^b}^,^{^c}
	CoQ10	5.7±0.5	6.7±0.4	10.4±0.5^{^a}^,^{^b}	8.7±0.3^{^a}^,^{^b}^,^{^c}
	GSH	1.59±0.11	1.33±0.03^{^a}	0.93±0.02^{^a}^,^{^b}	1.28±0.03^{^a}^,^{^c}
Muscle	GPX	2.6±0.1	2.3±0.2	2.8±0.2	2.5±0.1
	GR	0.67±0.04	0.61±0.03	0.81±0.05^{^b}	0.76±0.04^{^b}
	Vit E	12.7±0.3	10.0±0.7^{^a}	18.8±0.8^{^a}^,^{^b}	14.3±0.7^{^b}^,^{^c}
	CoQ9	36.4±0.8	34.8±0.6	46.9±1.6^{^a}^,^{^b}	41.1±0.6^{^a}^,^{^b}^,^{^c}
	CoQ10	2.9±0.2	3.0±0.1	3.7±0.2^{^a}^,^{^b}	3.6±0.2^{^a}^,^{^b}
	GSH	1.36±0.09	1.10±0.03^{^a}	0.90±0.03^{^a}^,^{^b}	1.11±0.03^{^a}^,^{^c}

Values are means ± s.e.m. For each value eight rats were used. Glutathione peroxidase activity (GPX) is expressed in μmol NADPH min^–1 g^–1 tissue. Glutathione reductase (GR)is expressed in μmol NADPH min^–1 g^–1tissue. Vitamin E (Vit E), coenzyme Q9 (CoQ9) and coenzyme Q10 (CoQ10) content is expressed in nmol g^–1 tissue. Reduced glutathione (GSH) is expressed in μmol g^–1 tissue

C, control euthyroid rats; H, hypothyroid rats; H+T₃,hypothyroid T₃-treated rats; H+GC-1, hypothyroid GC-1-treated rats

Significant vs C rats

significant vs H rats

significant vs H+T₃ rats. The level of significance was chosen as P<0.05

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