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Table 4.

Effect of T3 or GC-1 treatment of hypothyroid rats on oxidative damage of tissues

TissueParameterCHH+T3H+GC-1
Liver HPs 1.12±0.04 0.97±0.03a 2.26±0.06a,b 1.47±0.05a,b,c 
 CO 2.14±0.06 1.51±0.06a 2.75±0.12a,b 1.82±0.03a,b,c 
Heart HPs 0.22±0.01 0.19±0.01 0.30±0.02a,b 0.25±0.01b,c 
 CO 1.47±0.08 1.24±0.03a 2.52±0.11a,b 1.64±0.03b,c 
Muscle HPs 0.20±0.01 0.14±0.01a 0.24±0.02a,b 0.18±0.01b,c 
 CO 1.59±0.06 1.41±0.04a 2.04±0.08a,b 1.71±0.04b,c 
TissueParameterCHH+T3H+GC-1
Liver HPs 1.12±0.04 0.97±0.03a 2.26±0.06a,b 1.47±0.05a,b,c 
 CO 2.14±0.06 1.51±0.06a 2.75±0.12a,b 1.82±0.03a,b,c 
Heart HPs 0.22±0.01 0.19±0.01 0.30±0.02a,b 0.25±0.01b,c 
 CO 1.47±0.08 1.24±0.03a 2.52±0.11a,b 1.64±0.03b,c 
Muscle HPs 0.20±0.01 0.14±0.01a 0.24±0.02a,b 0.18±0.01b,c 
 CO 1.59±0.06 1.41±0.04a 2.04±0.08a,b 1.71±0.04b,c 

Values are means ± s.e.m. of eight different experiments. Hydroperoxides (HPs) are expressed in pmol NADP min–1g–1 tissue. Protein-bound carbonyls (CO) are expressed in nmol mg–1 protein

C, control euthyroid rats; H, hypothyroid rats; H+T3,hypothyroid T3-treated rats; H+GC-1, hypothyroid GC-1-treated rats

a

Significant vs C rats

b

significant vs H rats

c

significant vs H+T3 rats. The level of significance was chosen as P<0.05

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