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Table 4.

Effect of T₃ or GC-1 treatment of hypothyroid rats on oxidative damage of tissues

Tissue	Parameter	C	H	H+T3	H+GC-1
Liver	HPs	1.12±0.04	0.97±0.03^{^a}	2.26±0.06^{^a}^,^{^b}	1.47±0.05^{^a}^,^{^b}^,^{^c}
	CO	2.14±0.06	1.51±0.06^{^a}	2.75±0.12^{^a}^,^{^b}	1.82±0.03^{^a}^,^{^b}^,^{^c}
Heart	HPs	0.22±0.01	0.19±0.01	0.30±0.02^{^a}^,^{^b}	0.25±0.01^{^b}^,^{^c}
	CO	1.47±0.08	1.24±0.03^{^a}	2.52±0.11^{^a}^,^{^b}	1.64±0.03^{^b}^,^{^c}
Muscle	HPs	0.20±0.01	0.14±0.01^{^a}	0.24±0.02^{^a}^,^{^b}	0.18±0.01^{^b}^,^{^c}
	CO	1.59±0.06	1.41±0.04^{^a}	2.04±0.08^{^a}^,^{^b}	1.71±0.04^{^b}^,^{^c}

Tissue	Parameter	C	H	H+T3	H+GC-1
Liver	HPs	1.12±0.04	0.97±0.03^{^a}	2.26±0.06^{^a}^,^{^b}	1.47±0.05^{^a}^,^{^b}^,^{^c}
	CO	2.14±0.06	1.51±0.06^{^a}	2.75±0.12^{^a}^,^{^b}	1.82±0.03^{^a}^,^{^b}^,^{^c}
Heart	HPs	0.22±0.01	0.19±0.01	0.30±0.02^{^a}^,^{^b}	0.25±0.01^{^b}^,^{^c}
	CO	1.47±0.08	1.24±0.03^{^a}	2.52±0.11^{^a}^,^{^b}	1.64±0.03^{^b}^,^{^c}
Muscle	HPs	0.20±0.01	0.14±0.01^{^a}	0.24±0.02^{^a}^,^{^b}	0.18±0.01^{^b}^,^{^c}
	CO	1.59±0.06	1.41±0.04^{^a}	2.04±0.08^{^a}^,^{^b}	1.71±0.04^{^b}^,^{^c}

Values are means ± s.e.m. of eight different experiments. Hydroperoxides (HPs) are expressed in pmol NADP min^–1g^–1 tissue. Protein-bound carbonyls (CO) are expressed in nmol mg^–1 protein

C, control euthyroid rats; H, hypothyroid rats; H+T₃,hypothyroid T₃-treated rats; H+GC-1, hypothyroid GC-1-treated rats

Significant vs C rats

significant vs H rats

significant vs H+T₃ rats. The level of significance was chosen as P<0.05

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