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Table 3.

Effect of T3 or GC-1 treatment of hypothyroid rats on pyruvate/malate-sustained O2 consumption by heart homogenates

TissueCHH+T3H+GC-1
Liver State 4 0.88±0.03 0.66±0.04a 1.58±0.03a,b 1.21±0.05a,b,c 
 State 3 2.76±0.22 1.98±0.05a 5.49±0.05a,b 3.75±0.08a,b,c 
 RCR 3.1±0.1 3.0±0.2 3.5±0.3 3.1±0.2 
Heart State 4 1.36±0.05 0.92±0.02a 1.49±0.06b 1.02±0.02a,c 
 State 3 5.85±0.22 4.38±0.05a 6.46±0.16a,b 4.81±0.20a,c 
 RCR 4.3±0.3 4.7±0.3 4.3±0.2 4.8±0.1 
Muscle State 4 0.48±0.01 0.38±0.01a 0.59±0.02a,b 0.50±0.01b,c 
 State 3 2.00±0.11 1.57±0.05a 2.94±0.07a,b 2.14±0.04b,c 
 RCR 4.2±0.2 4.1±0.3 5.0±0.2a,b 4.3±0.2c 
TissueCHH+T3H+GC-1
Liver State 4 0.88±0.03 0.66±0.04a 1.58±0.03a,b 1.21±0.05a,b,c 
 State 3 2.76±0.22 1.98±0.05a 5.49±0.05a,b 3.75±0.08a,b,c 
 RCR 3.1±0.1 3.0±0.2 3.5±0.3 3.1±0.2 
Heart State 4 1.36±0.05 0.92±0.02a 1.49±0.06b 1.02±0.02a,c 
 State 3 5.85±0.22 4.38±0.05a 6.46±0.16a,b 4.81±0.20a,c 
 RCR 4.3±0.3 4.7±0.3 4.3±0.2 4.8±0.1 
Muscle State 4 0.48±0.01 0.38±0.01a 0.59±0.02a,b 0.50±0.01b,c 
 State 3 2.00±0.11 1.57±0.05a 2.94±0.07a,b 2.14±0.04b,c 
 RCR 4.2±0.2 4.1±0.3 5.0±0.2a,b 4.3±0.2c 

Values are means ± s.e.m. For each value eight rats were used. Oxygen consumption rates are expressed in μmol O2min–1 g–1 tissue

C, control euthyroid rats; H, hypothyroid rats; H+T3,hypothyroid T3-treated rats; H+GC-1, hypothyroid GC-1-treated rats

a

Significant vs C rats

b

significant vs H rats

c

significant vs H+T3 rats. The level of significance was chosen as P<0.05

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