The Company of Biologists

Table 3.

Effect of T₃ or GC-1 treatment of hypothyroid rats on pyruvate/malate-sustained O₂ consumption by heart homogenates

Tissue		C	H	H+T₃	H+GC-1
Liver	State 4	0.88±0.03	0.66±0.04^{^a}	1.58±0.03^{^a}^,^{^b}	1.21±0.05^{^a}^,^{^b}^,^{^c}
	State 3	2.76±0.22	1.98±0.05^{^a}	5.49±0.05^{^a}^,^{^b}	3.75±0.08^{^a}^,^{^b}^,^{^c}
	RCR	3.1±0.1	3.0±0.2	3.5±0.3	3.1±0.2
Heart	State 4	1.36±0.05	0.92±0.02^{^a}	1.49±0.06^{^b}	1.02±0.02^{^a}^,^{^c}
	State 3	5.85±0.22	4.38±0.05^{^a}	6.46±0.16^{^a}^,^{^b}	4.81±0.20^{^a}^,^{^c}
	RCR	4.3±0.3	4.7±0.3	4.3±0.2	4.8±0.1
Muscle	State 4	0.48±0.01	0.38±0.01^{^a}	0.59±0.02^{^a}^,^{^b}	0.50±0.01^{^b}^,^{^c}
	State 3	2.00±0.11	1.57±0.05^{^a}	2.94±0.07^{^a}^,^{^b}	2.14±0.04^{^b}^,^{^c}
	RCR	4.2±0.2	4.1±0.3	5.0±0.2^{^a}^,^{^b}	4.3±0.2^{^c}

Tissue		C	H	H+T₃	H+GC-1
Liver	State 4	0.88±0.03	0.66±0.04^{^a}	1.58±0.03^{^a}^,^{^b}	1.21±0.05^{^a}^,^{^b}^,^{^c}
	State 3	2.76±0.22	1.98±0.05^{^a}	5.49±0.05^{^a}^,^{^b}	3.75±0.08^{^a}^,^{^b}^,^{^c}
	RCR	3.1±0.1	3.0±0.2	3.5±0.3	3.1±0.2
Heart	State 4	1.36±0.05	0.92±0.02^{^a}	1.49±0.06^{^b}	1.02±0.02^{^a}^,^{^c}
	State 3	5.85±0.22	4.38±0.05^{^a}	6.46±0.16^{^a}^,^{^b}	4.81±0.20^{^a}^,^{^c}
	RCR	4.3±0.3	4.7±0.3	4.3±0.2	4.8±0.1
Muscle	State 4	0.48±0.01	0.38±0.01^{^a}	0.59±0.02^{^a}^,^{^b}	0.50±0.01^{^b}^,^{^c}
	State 3	2.00±0.11	1.57±0.05^{^a}	2.94±0.07^{^a}^,^{^b}	2.14±0.04^{^b}^,^{^c}
	RCR	4.2±0.2	4.1±0.3	5.0±0.2^{^a}^,^{^b}	4.3±0.2^{^c}

Values are means ± s.e.m. For each value eight rats were used. Oxygen consumption rates are expressed in μmol O₂min^–1 g^–1 tissue

C, control euthyroid rats; H, hypothyroid rats; H+T₃,hypothyroid T₃-treated rats; H+GC-1, hypothyroid GC-1-treated rats

Significant vs C rats

significant vs H rats

significant vs H+T₃ rats. The level of significance was chosen as P<0.05