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Table 2.

Effect of T3 or GC-1 treatment of hypothyroid rats on succinate-sustained O2 consumption by tissue homogenates

TissueCHH+T3H+GC-1
Liver State 4 2.62±0.08 2.40±0.06a 4.38±0.08a,b 3.74±0.08a,b,c 
 State 3 11.64±0.29 8.84±0.25a 24.79±0.48a,b 14.23±0.16a,b,c 
 RCR 4.6±0.3 3.5±0.2a 5.8±0.2a,b 3.8±0.1a,c 
Heart State 4 4.87±0.17 3.72±0.07a 6.43±0.10a,b 3.91±0.05a,c 
 State 3 11.46±0.51 10.17±0.16a 14.11±0.11a,b 10.65±0.30c 
 RCR 2.4±0.2 2.7±0.2 2.2±0.1 2.7±0.1 
Muscle State 4 1.92±0.06 1.63±0.04a 2.66±0.08a,b 1.83±0.03b,c 
 State 3 4.12±0.09 3.58±0.21a 6.55±0.10a,b 4.01±0.09b,c 
 RCR 2.1±0.1 2.2±0.1 2.5±0.1a 2.2±0.1 
TissueCHH+T3H+GC-1
Liver State 4 2.62±0.08 2.40±0.06a 4.38±0.08a,b 3.74±0.08a,b,c 
 State 3 11.64±0.29 8.84±0.25a 24.79±0.48a,b 14.23±0.16a,b,c 
 RCR 4.6±0.3 3.5±0.2a 5.8±0.2a,b 3.8±0.1a,c 
Heart State 4 4.87±0.17 3.72±0.07a 6.43±0.10a,b 3.91±0.05a,c 
 State 3 11.46±0.51 10.17±0.16a 14.11±0.11a,b 10.65±0.30c 
 RCR 2.4±0.2 2.7±0.2 2.2±0.1 2.7±0.1 
Muscle State 4 1.92±0.06 1.63±0.04a 2.66±0.08a,b 1.83±0.03b,c 
 State 3 4.12±0.09 3.58±0.21a 6.55±0.10a,b 4.01±0.09b,c 
 RCR 2.1±0.1 2.2±0.1 2.5±0.1a 2.2±0.1 

Values are means ± s.e.m. For each value eight rats were used. Oxygen consumption rates are expressed in μmol O2min–1 g–1 tissue

C, control euthyroid rats; H, hypothyroid rats; H+T3,hypothyroid T3-treated rats; H+GC-1, hypothyroid GC-1-treated rats

a

Significant vs C rats

b

significant vs H rats

c

significant vs H+T3 rats. The level of significance was chosen as P<0.05

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