The Company of Biologists

Table 2.

Effect of T₃ or GC-1 treatment of hypothyroid rats on succinate-sustained O₂ consumption by tissue homogenates

Tissue		C	H	H+T₃	H+GC-1
Liver	State 4	2.62±0.08	2.40±0.06^{^a}	4.38±0.08^{^a}^,^{^b}	3.74±0.08^{^a}^,^{^b}^,^{^c}
	State 3	11.64±0.29	8.84±0.25^{^a}	24.79±0.48^{^a}^,^{^b}	14.23±0.16^{^a}^,^{^b}^,^{^c}
	RCR	4.6±0.3	3.5±0.2^{^a}	5.8±0.2^{^a}^,^{^b}	3.8±0.1^{^a}^,^{^c}
Heart	State 4	4.87±0.17	3.72±0.07^{^a}	6.43±0.10^{^a}^,^{^b}	3.91±0.05^{^a}^,^{^c}
	State 3	11.46±0.51	10.17±0.16^{^a}	14.11±0.11^{^a}^,^{^b}	10.65±0.30^{^c}
	RCR	2.4±0.2	2.7±0.2	2.2±0.1	2.7±0.1
Muscle	State 4	1.92±0.06	1.63±0.04^{^a}	2.66±0.08^{^a}^,^{^b}	1.83±0.03^{^b}^,^{^c}
	State 3	4.12±0.09	3.58±0.21^{^a}	6.55±0.10^{^a}^,^{^b}	4.01±0.09^{^b}^,^{^c}
	RCR	2.1±0.1	2.2±0.1	2.5±0.1^{^a}	2.2±0.1

Tissue		C	H	H+T₃	H+GC-1
Liver	State 4	2.62±0.08	2.40±0.06^{^a}	4.38±0.08^{^a}^,^{^b}	3.74±0.08^{^a}^,^{^b}^,^{^c}
	State 3	11.64±0.29	8.84±0.25^{^a}	24.79±0.48^{^a}^,^{^b}	14.23±0.16^{^a}^,^{^b}^,^{^c}
	RCR	4.6±0.3	3.5±0.2^{^a}	5.8±0.2^{^a}^,^{^b}	3.8±0.1^{^a}^,^{^c}
Heart	State 4	4.87±0.17	3.72±0.07^{^a}	6.43±0.10^{^a}^,^{^b}	3.91±0.05^{^a}^,^{^c}
	State 3	11.46±0.51	10.17±0.16^{^a}	14.11±0.11^{^a}^,^{^b}	10.65±0.30^{^c}
	RCR	2.4±0.2	2.7±0.2	2.2±0.1	2.7±0.1
Muscle	State 4	1.92±0.06	1.63±0.04^{^a}	2.66±0.08^{^a}^,^{^b}	1.83±0.03^{^b}^,^{^c}
	State 3	4.12±0.09	3.58±0.21^{^a}	6.55±0.10^{^a}^,^{^b}	4.01±0.09^{^b}^,^{^c}
	RCR	2.1±0.1	2.2±0.1	2.5±0.1^{^a}	2.2±0.1

Values are means ± s.e.m. For each value eight rats were used. Oxygen consumption rates are expressed in μmol O₂min^–1 g^–1 tissue

C, control euthyroid rats; H, hypothyroid rats; H+T₃,hypothyroid T₃-treated rats; H+GC-1, hypothyroid GC-1-treated rats

Significant vs C rats

significant vs H rats

significant vs H+T₃ rats. The level of significance was chosen as P<0.05