The Company of Biologists

Table 1.

Effect of T₃ or GC-1 treatment on body parameters, heart rate,resting metabolic rate, and serum levels of cholesterol and free iodothyronines

Parameter	C	H	H+T₃	H+GC-1
Body mass (g)	267.0±4.1	276.1±6.0	247.3±8.2^{^a}^,^{^b}	270.4±7.3^{^c}
Heart mass (mg)	670±20	550±10^{^a}	790±50^{^a}^,^{^b}	640±30^{^c}
Heart mass/body mass (mg g^–1)	2.50±0.04	2.01±0.03^{^a}	3.23±0.15^{^a}^,^{^b}	2.34±0.06^{^b}^,^{^c}
Heart rate (beats min^–1)	357±12	278±9^{^a}	534±12^{^a}^,^{^b}	367±7^{^b}^,^{^c}
RMR (l O₂ kg^–1 h^–1)	1.10±0.02	1.01±0.03^{^a}	1.57±0.01^{^a}^,^{^b}	1.12±0.03^{^b}^,^{^c}
Cholesterol (mg dl^–1)	46.6±1.4	63.7±1.6^{^a}	41.8±1.7^{^b}	46.6±1.6^{^b}
FT₃ (pg dl^–1)	301±24	25.5±5.1^{^a}	571.0±57.5^{^a}^,^{^b}	26.4±4.9^{^a}^,^{^c}
FT₄ (ng dl^–1)	1.45±0.09	0.33±0.04^{^a}	0.39±0.04^{^a}	0.30±0.03^{^a}

Parameter	C	H	H+T₃	H+GC-1
Body mass (g)	267.0±4.1	276.1±6.0	247.3±8.2^{^a}^,^{^b}	270.4±7.3^{^c}
Heart mass (mg)	670±20	550±10^{^a}	790±50^{^a}^,^{^b}	640±30^{^c}
Heart mass/body mass (mg g^–1)	2.50±0.04	2.01±0.03^{^a}	3.23±0.15^{^a}^,^{^b}	2.34±0.06^{^b}^,^{^c}
Heart rate (beats min^–1)	357±12	278±9^{^a}	534±12^{^a}^,^{^b}	367±7^{^b}^,^{^c}
RMR (l O₂ kg^–1 h^–1)	1.10±0.02	1.01±0.03^{^a}	1.57±0.01^{^a}^,^{^b}	1.12±0.03^{^b}^,^{^c}
Cholesterol (mg dl^–1)	46.6±1.4	63.7±1.6^{^a}	41.8±1.7^{^b}	46.6±1.6^{^b}
FT₃ (pg dl^–1)	301±24	25.5±5.1^{^a}	571.0±57.5^{^a}^,^{^b}	26.4±4.9^{^a}^,^{^c}
FT₄ (ng dl^–1)	1.45±0.09	0.33±0.04^{^a}	0.39±0.04^{^a}	0.30±0.03^{^a}

Values are means ± s.e.m. For each value eight rats were used

RMR, resting metabolic rate; FT₃ and FT₄, serum level of free triiodothyronine and thyroxine, respectively; C, control euthyroid rats; H, hypothyroid rats; H+T₃, hypothyroid T₃-treated rats; H+GC-1, hypothyroid GC-1-treated rats

Significant vs C rats

significant vs H rats

significant vs H+T₃ rats. The level of significance was chosen as P<0.05

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