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Table 2.

Inhibition of the V-ATPase activity and cell growth by apicularen

CompoundV1VO holoenzyme Manduca sextaaIC50 (μmol l–1)Growth inhibition Murine cell line L-929b IC50 (μmol l–1)
Apicularen A 0.02 0.005 
Apicularen B 0.06 0.6 
N-methyl-apicularen 0.2 0.8 
11-deoxy-apicularen 0.02 0.02 
Open apicularen 0.02 0.2 
Oxime apicularen 0.2 
Enyne apicularen 
CompoundV1VO holoenzyme Manduca sextaaIC50 (μmol l–1)Growth inhibition Murine cell line L-929b IC50 (μmol l–1)
Apicularen A 0.02 0.005 
Apicularen B 0.06 0.6 
N-methyl-apicularen 0.2 0.8 
11-deoxy-apicularen 0.02 0.02 
Open apicularen 0.02 0.2 
Oxime apicularen 0.2 
Enyne apicularen 

Data taken from aHuss et al.(Huss et al., 2005), M.H., M. E. Maier and H.W. (unpublished observations), and bPetri et al.(Petri et al., 2005)

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