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Table 1.

Inhibition of the V-ATPase activity and cell growth by archazolids

CompoundV1VO holoenzyme Manduca sexta IC50(μmol l–1)Growth inhibition murine cell line L-929 IC50 (μmol l–1)
Archazolid A 0.02 0.001 
Archazolid B 0.02 0.001 
Archazolid C 
Archazolid D 15 0.3 
15-dehydro-archazolid A 0.3 >5 
1′-descarbamoyl-archazolid A 0.1 0.01 
7-O-p-Nitrobenzoate-archazolid A 0.3 
7-O-TBS-archazolid A 0.9 
CompoundV1VO holoenzyme Manduca sexta IC50(μmol l–1)Growth inhibition murine cell line L-929 IC50 (μmol l–1)
Archazolid A 0.02 0.001 
Archazolid B 0.02 0.001 
Archazolid C 
Archazolid D 15 0.3 
15-dehydro-archazolid A 0.3 >5 
1′-descarbamoyl-archazolid A 0.1 0.01 
7-O-p-Nitrobenzoate-archazolid A 0.3 
7-O-TBS-archazolid A 0.9 

Data taken from Huss et al. (Huss et al., 2005) and Menche et al.(Menche et al., 2007a; Menche et al., 2007b; Menche et al., 2007c)

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