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Table 1.

Biophysical parameters determined in this study

CionaKv4
ntCionaKv4
Biophysical parameterCionaKChIP+CionaKChIPCionaKChIP+CionaKChIP
Ipeak (pA) at +50 mV 207±27 (15) 867±62(17)a 370±65.2 (15) 432±97 (15) 
τact (ms) at +50 mV 3.4±0.2 (11) 3.3±0.2 (10) 3.2±0.3 (12) 3.5±0.3 (12) 
Inactivation (ms) at +50 mV     
τ1 26±2 (15) 291±42 (9) 56±6 (15) 240±29 (8) 
I1 82% 100% 49% 100% 
τ2 147±26 (15) 381±50 (15) 
I2 18% 51% 
τrec (ms) at −100 mV 387±47 (7) 927±47(6)a 331±51 (8) 587±76(8)b 
τdeact (ms) at −130 mV 4.1±0.3 (10) 8.3±0.4(16)a 5.7±0.6 (12) 6.5±0.6 (10) 
Steady-state activation (mV)     
V0.5 −0.5±1.7 (15) −29.2±1.1(17)a −12.3±1.6 (15) −15.2±1.3 (15) 
K 15.5±0.8 (15) 13.4±0.3 (17) 14.3±0.4 (15) 13.4±0.2 (15) 
Steady-state inactivation (mV)     
V0.5 −72±2 (7) −88±2(7)a −73±2 (7) −74±2 (8) 
K 3.6±0.2 (7) 4.3±0.2(7)a 3.7±0.2 (7) 4.1±0.3 (8) 
CionaKv4
ntCionaKv4
Biophysical parameterCionaKChIP+CionaKChIPCionaKChIP+CionaKChIP
Ipeak (pA) at +50 mV 207±27 (15) 867±62(17)a 370±65.2 (15) 432±97 (15) 
τact (ms) at +50 mV 3.4±0.2 (11) 3.3±0.2 (10) 3.2±0.3 (12) 3.5±0.3 (12) 
Inactivation (ms) at +50 mV     
τ1 26±2 (15) 291±42 (9) 56±6 (15) 240±29 (8) 
I1 82% 100% 49% 100% 
τ2 147±26 (15) 381±50 (15) 
I2 18% 51% 
τrec (ms) at −100 mV 387±47 (7) 927±47(6)a 331±51 (8) 587±76(8)b 
τdeact (ms) at −130 mV 4.1±0.3 (10) 8.3±0.4(16)a 5.7±0.6 (12) 6.5±0.6 (10) 
Steady-state activation (mV)     
V0.5 −0.5±1.7 (15) −29.2±1.1(17)a −12.3±1.6 (15) −15.2±1.3 (15) 
K 15.5±0.8 (15) 13.4±0.3 (17) 14.3±0.4 (15) 13.4±0.2 (15) 
Steady-state inactivation (mV)     
V0.5 −72±2 (7) −88±2(7)a −73±2 (7) −74±2 (8) 
K 3.6±0.2 (7) 4.3±0.2(7)a 3.7±0.2 (7) 4.1±0.3 (8) 

For definitions of parameters, see List of symbols.

a

Significantly different from CionaKv4 (P<0.01).

b

Significantly different from ntCionaKv4(0.01<P<0.05).

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