Table 2.

Summary of protective roles of counteracting solutes through stabilization of macromolecules and membranes

Stabilising propertyCounteracting solutes in nature
Counteract urea inhibition Methylamines, especially TMAO (e.g. shark) 
Increase thermostability Trehalose, anionic polyols (e.g. vent archaeon) 
Protect membranes in freezing Trehalose; proline (e.g. frozen insect) 
Preserve in dry state Carbohydrates, especially trehalose (e.g. dried yeast) 
Counteract inorganic ion inhibition Methylamines (e.g. salt marsh plant) 
Counteract hydrostatic pressure TMAO; other solutes? (e.g. deep-sea fish) 
Stabilising propertyCounteracting solutes in nature
Counteract urea inhibition Methylamines, especially TMAO (e.g. shark) 
Increase thermostability Trehalose, anionic polyols (e.g. vent archaeon) 
Protect membranes in freezing Trehalose; proline (e.g. frozen insect) 
Preserve in dry state Carbohydrates, especially trehalose (e.g. dried yeast) 
Counteract inorganic ion inhibition Methylamines (e.g. salt marsh plant) 
Counteract hydrostatic pressure TMAO; other solutes? (e.g. deep-sea fish) 
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