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Table 1.

The most highly conserved stress response proteins

Gene (Homo sapiens)Stress response functionDrosophila melanogaster (%identity/%similarity)Halobacterium sp. (%identity/%similarity)Escherichia coli (%identity/%similarity)
HSP70/dnaK (P08107) Molecular chaperone P11147 (83/91) Q9HRY2 (47/63) P04475 (50/64) 
HSP40/dnaJ (O60884) Molecular chaperone Q9VFV9 (50/65) Q9HRY3 (31/47) P08622 (34/49) 
PRS1/ftsH (P35998) Proteasome pathway, Cell cycle checkpoint Q9V478 (91/95) Q9HNP9 (47/67) P28691 (42/63) 
PRS2/ftsH (Q9Y4W6) Proteasome pathway, Cell cycle checkpoint Q9VVE6 (63/75) Q9HRW6 (40/60) P28691 (49/67) 
SelB (Q9BX10) Selenocysteine-specific elongation factor, Free radical scavenging AAF51935 (50/68) Q9HPE4 (30/49) P14081 (24/39) 
MSH/mutS (P43246) DNA repair AAF53392 (44/64) Q9HSM2 (30/48) P23909 (32/50) 
Lon protease (P36776) Stress response protease Q9VW20 (63/76) Q9HSC3 (32/49) P08177 (40/61) 
HSP60/Cpn60 (P10809) Molecular chaperone, Cell cycle regulation O02649 (73/85) Q9HNI0 (24/42) P06139 (50/72) 
DNA topoisomerase III/(I) (Q13472) Chromosome maintenance, DNA repair Q9NG98 (58/70) Q9HS90 (27/44) P06612 (25/40) 
Glutathione reductase (Q16881) Free radical scavenging AAN09228 (55/68) Q9HN74 (25/44) P06715 (36/53) 
MLH/mutL (P40692) DNA repair Q9V380 (45/61) Q9HSM6 (33/50) P23367 (35/57) 
Peptide methionine sulfoxide reductase (Q9UJ68) Free radical scavenging, Protein repair AAF4963 (40/55) Q9HQG0 (42/59) P27110 (60/72) 
Gene (Homo sapiens)Stress response functionDrosophila melanogaster (%identity/%similarity)Halobacterium sp. (%identity/%similarity)Escherichia coli (%identity/%similarity)
HSP70/dnaK (P08107) Molecular chaperone P11147 (83/91) Q9HRY2 (47/63) P04475 (50/64) 
HSP40/dnaJ (O60884) Molecular chaperone Q9VFV9 (50/65) Q9HRY3 (31/47) P08622 (34/49) 
PRS1/ftsH (P35998) Proteasome pathway, Cell cycle checkpoint Q9V478 (91/95) Q9HNP9 (47/67) P28691 (42/63) 
PRS2/ftsH (Q9Y4W6) Proteasome pathway, Cell cycle checkpoint Q9VVE6 (63/75) Q9HRW6 (40/60) P28691 (49/67) 
SelB (Q9BX10) Selenocysteine-specific elongation factor, Free radical scavenging AAF51935 (50/68) Q9HPE4 (30/49) P14081 (24/39) 
MSH/mutS (P43246) DNA repair AAF53392 (44/64) Q9HSM2 (30/48) P23909 (32/50) 
Lon protease (P36776) Stress response protease Q9VW20 (63/76) Q9HSC3 (32/49) P08177 (40/61) 
HSP60/Cpn60 (P10809) Molecular chaperone, Cell cycle regulation O02649 (73/85) Q9HNI0 (24/42) P06139 (50/72) 
DNA topoisomerase III/(I) (Q13472) Chromosome maintenance, DNA repair Q9NG98 (58/70) Q9HS90 (27/44) P06612 (25/40) 
Glutathione reductase (Q16881) Free radical scavenging AAN09228 (55/68) Q9HN74 (25/44) P06715 (36/53) 
MLH/mutL (P40692) DNA repair Q9V380 (45/61) Q9HSM6 (33/50) P23367 (35/57) 
Peptide methionine sulfoxide reductase (Q9UJ68) Free radical scavenging, Protein repair AAF4963 (40/55) Q9HQG0 (42/59) P27110 (60/72) 

Gene products with one or more known function(s) in the cellular stress response that are most highly conserved in all three super-kingdoms of life are listed

The data were acquired by BLAST sequence comparison of whole proteomes of Drosophila melanogaster, Halobacterium sp. (strain NRC1), and Escherichia coli (K12) against the whole human proteome (expectation value=10-10, matrix=BLOSUM62). Of 33,633 human proteins compared to the other three proteomes, 368 proteins representing the most highly conserved in all three super-kingdoms were identified using PyMood software (Allometra,Inc., http://allometra.com/). 12 of these 368 proteins with known roles in the cellular stress response are identified by name and Swiss-Prot/TrEMBL accession number in the table

The degree of identity and similarity to the respective orthologous human sequence are also shown

Multiple paralogous genes encoding these stress response proteins in humans(only one is shown in the table) account for 67 (18%) of the 368 phylogenetically most highly conserved proteins

Proteasome regulatory subunits 1 and 2 (PRS1, 2) are encoded by the same gene in E. coli

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