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Table 2.

The effect of mosquito natriuretic peptide (MNP) and its second messenger cAMP on transepithelial electrolyte and fluid secretion in isolated Malpighian tubules of Aedes aegypti

Experimental condition (N tubules)Fluid secretion (nl min−1)[Na+]sf (mmol l−1)[K+]sf (mmol l−1)[Cl]sf (mmol l−1)
Control (44) 0.65±0.03 76±3 114±3 181±3 
MNP (10) 2.08±0.27 * 134±4 * 36±5 * 166±3 
cAMP (5-7) 2.9±0.2 * 178±7 * 17±1 * 185±4 
  Na+ secretion (pmol min−1K+ secretion (pmol min−1Cl secretion (pmol min−1
Control (44)  51±4 75±4 119±6 
MNP (10)  302±30 * 69±7 352±33 * 
cAMP (5−25)  454±43 * 43±6 451±50 * 
Experimental condition (N tubules)Fluid secretion (nl min−1)[Na+]sf (mmol l−1)[K+]sf (mmol l−1)[Cl]sf (mmol l−1)
Control (44) 0.65±0.03 76±3 114±3 181±3 
MNP (10) 2.08±0.27 * 134±4 * 36±5 * 166±3 
cAMP (5-7) 2.9±0.2 * 178±7 * 17±1 * 185±4 
  Na+ secretion (pmol min−1K+ secretion (pmol min−1Cl secretion (pmol min−1
Control (44)  51±4 75±4 119±6 
MNP (10)  302±30 * 69±7 352±33 * 
cAMP (5−25)  454±43 * 43±6 451±50 * 

The concentrations of Na+, K+ and Cl were measured in picoliter volumes of secreted fluid by electron-probe (X-ray) analysis. Ion secretion rates are the product of fluid secretion and molar concentration. Data are from Petzel et al.(1985). Peritubular concentrations were 151.8 mmol l−1, 3.4 mmol l−1 and 158.0 mmol l−1 for Na+,K+ and Cl, respectively. sf, secreted fluid. *P<0.05.

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