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Table 1.

Heterologous prime-boost immunisation and protection againstPlasmodium berghei sporozoite challenge

Immunization 1Immunization 2Number infectedProtection (%)
DNA−CS+TRAP DNA−CS+TRAP 5/5 
MVA−CS+TRAP MVA−CS+TRAP 4/5 20 
DNA−CS MVA−CS 0/10 100 
DNA−TRAP MVA−TRAP 2/16 88 
DNA−CS+TRAP MVA−CS+TRAP 0/10 100 
MVA−CS+TRAP DNA−CS+TRAP 5/5 
DNA−epitope MVA−epitope 0/10 100 
None None 9/10 10 
Immunization 1Immunization 2Number infectedProtection (%)
DNA−CS+TRAP DNA−CS+TRAP 5/5 
MVA−CS+TRAP MVA−CS+TRAP 4/5 20 
DNA−CS MVA−CS 0/10 100 
DNA−TRAP MVA−TRAP 2/16 88 
DNA−CS+TRAP MVA−CS+TRAP 0/10 100 
MVA−CS+TRAP DNA−CS+TRAP 5/5 
DNA−epitope MVA−epitope 0/10 100 
None None 9/10 10 

TRAP, thrombospondin-related adhesion protein; MVA, modified vaccinia virus Ankara; CS, circumsporozoite protein.

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