Skip to Main Content
Table 1.

Approaches to antimalarial drug discovery and development

ApproachExamplesReferences
Optimize therapy with existing agents Amodiaquine/sulfadoxine/pyrimethamine Staedke et al., 2001; Dorsey et al., 2002; Schellenberg et al., 2002 
 Amodiaquine/artesunate Adjuik et al., 2002 
 Artesunate/sulfadoxine/pyrimethamine von Seidlein et al., 2000; Dorsey et al., 2002 
 Artesunate/mefloquine Price et al., 1997 
 Artemether/lumefantrine Lefevre et al., 2001 
 Chlorproguanil/dapsone Nzila et al., 2000; Mutabingwa et al., 2001; Kublin et al., 2002 
 Chlorproguanil/dapsone/artesunate 
 Atovaquone/proguanil Vaidya, 2001 
Develop analogs of existing agents New aminoquinolines Raynes et al., 1999; Kaschula et al., 2002 
 New endoperoxides Vennerstrom et al., 2000; Posner et al., 2003 
 New folate antagonists Tarnchompoo et al., 2002 
Natural products New natural products Tagboto and Townson, 2001 
Compounds active against other diseases Folate antagonists Plowe, 2001 
 Antibiotics Clough and Wilson, 2001 
 Atovaquone Vaidya, 2001 
 Iron chelators Loyevsky and Gordeuk, 2001 
Drug resistance reversers Verapamil, desipramine, trifluoperazine van Schalkwyk et al., 2001 
 Chlorpheniramine Sowunmi et al., 1997 
Compounds active against new targets See Table 2  
ApproachExamplesReferences
Optimize therapy with existing agents Amodiaquine/sulfadoxine/pyrimethamine Staedke et al., 2001; Dorsey et al., 2002; Schellenberg et al., 2002 
 Amodiaquine/artesunate Adjuik et al., 2002 
 Artesunate/sulfadoxine/pyrimethamine von Seidlein et al., 2000; Dorsey et al., 2002 
 Artesunate/mefloquine Price et al., 1997 
 Artemether/lumefantrine Lefevre et al., 2001 
 Chlorproguanil/dapsone Nzila et al., 2000; Mutabingwa et al., 2001; Kublin et al., 2002 
 Chlorproguanil/dapsone/artesunate 
 Atovaquone/proguanil Vaidya, 2001 
Develop analogs of existing agents New aminoquinolines Raynes et al., 1999; Kaschula et al., 2002 
 New endoperoxides Vennerstrom et al., 2000; Posner et al., 2003 
 New folate antagonists Tarnchompoo et al., 2002 
Natural products New natural products Tagboto and Townson, 2001 
Compounds active against other diseases Folate antagonists Plowe, 2001 
 Antibiotics Clough and Wilson, 2001 
 Atovaquone Vaidya, 2001 
 Iron chelators Loyevsky and Gordeuk, 2001 
Drug resistance reversers Verapamil, desipramine, trifluoperazine van Schalkwyk et al., 2001 
 Chlorpheniramine Sowunmi et al., 1997 
Compounds active against new targets See Table 2  
Close Modal

or Create an Account

Close Modal
Close Modal