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Table 1.

Influence of genotype on the penetrance of craniosynostosis

GenotypeNumber of mice with fused coronal suture
Wild type 0/20 
EphA4+/− 0/16 
Efna2−/− 0/9 
EphA4+/−; Efna2+/− 0/14 
EphA4−/− 8/20* 
EphA4−/−; Efna2+/− 8/17* 
Twist1+/− 19/26 
Twist1+/−; EphA4+/− 31/33 
GenotypeNumber of mice with fused coronal suture
Wild type 0/20 
EphA4+/− 0/16 
Efna2−/− 0/9 
EphA4+/−; Efna2+/− 0/14 
EphA4−/− 8/20* 
EphA4−/−; Efna2+/− 8/17* 
Twist1+/− 19/26 
Twist1+/−; EphA4+/− 31/33 

Fusion of the coronal suture was assessed at P21 in Alizarin Red S-stained whole-mount skulls.

*

No significant difference in penetrance was observed between EphA4−/− and EphA4−/−; EphA2+/−(P>0.05).

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