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Table 1.

Fertility and incidence of anal atresia in TC/+ mice associated with genetic background

Genetic backgroundPercentage of successful matings*Total number of littersAverage litter size (average number of litters per pair)+/+ Offspring (% with anal atresia)TC/+ Offspring (% with anal atresia)P-value for χ2 analyses of Mendelian inheritance
C3.Cg-TC 48.9 38 6.2 (2.2) 165 (0) 73 (33.0≤1 × 10−13 
B6.C3(Cg)-TC 45.8 30 6.6 (2.7) 117 (0) 81 (19.8‡) ≤0.001 
STOCK-TC/JDown 69.2 141 8.1 (3.9) 586 (0) 557 (6.29§) 0.26 
Genetic backgroundPercentage of successful matings*Total number of littersAverage litter size (average number of litters per pair)+/+ Offspring (% with anal atresia)TC/+ Offspring (% with anal atresia)P-value for χ2 analyses of Mendelian inheritance
C3.Cg-TC 48.9 38 6.2 (2.2) 165 (0) 73 (33.0≤1 × 10−13 
B6.C3(Cg)-TC 45.8 30 6.6 (2.7) 117 (0) 81 (19.8‡) ≤0.001 
STOCK-TC/JDown 69.2 141 8.1 (3.9) 586 (0) 557 (6.29§) 0.26 

The total live-born offspring recovered from TC/+X+/+ matings was used to determine expected values for ϰ2 analyses on each genetic background. For C3H.Cg-TC,B6.C3(Cg)-TC and STOCK-TC/JDown,ϰ2=35.56, 6.55 and 0.74, respectively.

8.33%, 75.0% and §28.5% of these also displayed hindlimb defects and a grossly shortened body.

*

At least 24 breeding pairs of each background were paired continuously for 4 months. Failure to produce a litter within this window was classified as infertile.

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