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Table 1.

Phenotypes in normal and abnormal uterine and cervicovaginal epithelia

Müllerian vagina/cervix
Uterus
p63+
p63+
UtE/VgS-TR

Müllerian duct (E16)
Normal
Adenosis*
p63-/-*
Normal
SQM
p63-/-
p63+*
Epithelial typeColumnarSquamousColumnarColumnarColumnarSquamousColumnarColumnar
Inclusion/gland 
ERα 
p130 
p63 
K14 
K19 
P-cadherin 
K10 
Involucrin 
K8 - 
PR (-E2) 
PR (+E2) 
Müllerian vagina/cervix
Uterus
p63+
p63+
UtE/VgS-TR

Müllerian duct (E16)
Normal
Adenosis*
p63-/-*
Normal
SQM
p63-/-
p63+*
Epithelial typeColumnarSquamousColumnarColumnarColumnarSquamousColumnarColumnar
Inclusion/gland 
ERα 
p130 
p63 
K14 
K19 
P-cadherin 
K10 
Involucrin 
K8 - 
PR (-E2) 
PR (+E2) 
*

Epithelial phenotypes of p63+ cervicovaginal adenosis, p63-/- cervix/vagina and adult-UtE+VgS tissue recombinants were identical.

Epithelial phenotypes of p63+ cervix/vagina and uterine SQM were identical.

Vagina only.

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