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Table 1.

Deficiency of collagen IV causes embryonic lethality at E10.5-E11.5

StageLittersResorbedn+/++/--/-% expected (-/-)
E9.5 22 184 53 87 44 94 
E10-10.5 23 189 58 96 35 68 
E11-11.5 10 20 62 16 42 21 
E12.5 19 68 19 49 
Adult 18  119 43 76 
StageLittersResorbedn+/++/--/-% expected (-/-)
E9.5 22 184 53 87 44 94 
E10-10.5 23 189 58 96 35 68 
E11-11.5 10 20 62 16 42 21 
E12.5 19 68 19 49 
Adult 18  119 43 76 

Embryos at the indicated stages were isolated from intercrosses of heterozygous animals and the total number of intact (n) as well as disintegrated or resorbed embryos are indicated. Calculation of % expected(-/-): n(-/-)×100×3/n(+/+)+n(+/-).

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