The Company of Biologists

Table 2.

Downstream effectors of planar polarity

Name	Symbol	Molecular homology	Requirement in wing/eye	Planar polarity effector in vertebrates?	References
inturned	in	Predicted transmembrane protein	Wing hair number and polarity	Unknown	Gubb and García-Bellido, 1982; Wong and Adler, 1993; Park et al., 1996
fuzzy	fy	Predicted fourpass transmembrane protein	Wing hair number and polarity	Unknown	Gubb and García-Bellido, 1982; Wong and Adler, 1993; Collier and Gubb,1997
multiple-wing-hairs	mwh	Unknown	Wing hair number and polarity	Unknown	Gubb and García-Bellido, 1982; Wong and Adler, 1993
RhoA	RhoA	p21 GTPase of Rho family	Wing hair number; ommatidial rotation	Xenopus CE	Strutt et al., 1997; Wünnenberg-Stapleton et al., 1999
Rho-associated kinase	Drok	Protein kinase that acts as Rho effector	Wing hair number; ommatidial rotation	Zebrafish CE	Winter et al., 2001; Marlow et al., 2002
Notch	N	Transmembrane receptor	Ommatidial chirality	Unknown	Cooper and Bray, 1999; Fanto and Mlodzik, 1999; Tomlinson and Struhl, 1999
Delta	Dl	Notch ligand	Ommatidial chirality	Unknown	Cooper and Bray, 1999; Fanto and Mlodzik, 1999; Tomlinson and Struhl, 1999
nemo	nmo	Serine/threonine kinase	Ommatidial rotation; (also wing hair polarity?)	Unknown	Choi and Benzer, 1994; Verheyen et al., 2001
roulette	rlt	Unknown	Ommatidial rotation	Unknown	Choi and Benzer, 1994
basket (and other JNK cascade components)	bsk	Jun N-terminal kinase	No phenotype	Unknown	Strutt et al., 1997; Boutros et al., 1998; Strutt et al., 2002
Djun	Djun	Jun/Ap-1 transcription factor	Weak phenotype in ommatidial rotation and chirality	Xenopus CE	Boutros et al., 1998; Weber et al., 2000; Strutt et al., 2002

Name	Symbol	Molecular homology	Requirement in wing/eye	Planar polarity effector in vertebrates?	References
inturned	in	Predicted transmembrane protein	Wing hair number and polarity	Unknown	Gubb and García-Bellido, 1982; Wong and Adler, 1993; Park et al., 1996
fuzzy	fy	Predicted fourpass transmembrane protein	Wing hair number and polarity	Unknown	Gubb and García-Bellido, 1982; Wong and Adler, 1993; Collier and Gubb,1997
multiple-wing-hairs	mwh	Unknown	Wing hair number and polarity	Unknown	Gubb and García-Bellido, 1982; Wong and Adler, 1993
RhoA	RhoA	p21 GTPase of Rho family	Wing hair number; ommatidial rotation	Xenopus CE	Strutt et al., 1997; Wünnenberg-Stapleton et al., 1999
Rho-associated kinase	Drok	Protein kinase that acts as Rho effector	Wing hair number; ommatidial rotation	Zebrafish CE	Winter et al., 2001; Marlow et al., 2002
Notch	N	Transmembrane receptor	Ommatidial chirality	Unknown	Cooper and Bray, 1999; Fanto and Mlodzik, 1999; Tomlinson and Struhl, 1999
Delta	Dl	Notch ligand	Ommatidial chirality	Unknown	Cooper and Bray, 1999; Fanto and Mlodzik, 1999; Tomlinson and Struhl, 1999
nemo	nmo	Serine/threonine kinase	Ommatidial rotation; (also wing hair polarity?)	Unknown	Choi and Benzer, 1994; Verheyen et al., 2001
roulette	rlt	Unknown	Ommatidial rotation	Unknown	Choi and Benzer, 1994
basket (and other JNK cascade components)	bsk	Jun N-terminal kinase	No phenotype	Unknown	Strutt et al., 1997; Boutros et al., 1998; Strutt et al., 2002
Djun	Djun	Jun/Ap-1 transcription factor	Weak phenotype in ommatidial rotation and chirality	Xenopus CE	Boutros et al., 1998; Weber et al., 2000; Strutt et al., 2002

CE, convergent extension; JNK, Jun-N-terminal-kinase.