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Table 1.

Kidney abnormalities in newborn compound heterozygotes of Eya1and Six1

GenotypenSmall kidneyNo kidney
Wild type 129 13 
Eya1+/- 129 17 3* 
Six1+/- 129 19 2 One bilateral 
Eya1+/-/Six1+/- 129 21 15 Five bilateral, one unilateral 
Wild type C57BL6 16 One unilateral 
Eya1+/- C57BL6 13 1§ 
Six1+/- C57BL6 12 
Eya1+/-/Six1+/- C57BL6 14 10 Four unilateral 
GenotypenSmall kidneyNo kidney
Wild type 129 13 
Eya1+/- 129 17 3* 
Six1+/- 129 19 2 One bilateral 
Eya1+/-/Six1+/- 129 21 15 Five bilateral, one unilateral 
Wild type C57BL6 16 One unilateral 
Eya1+/- C57BL6 13 1§ 
Six1+/- C57BL6 12 
Eya1+/-/Six1+/- C57BL6 14 10 Four unilateral 

n, number of animals

*

Three Eya1+/- 129 animals showed unilaterally smaller kidney with reduction of ∼10% in weight

Two Six1+/- 129 animals showed smaller kidneys on one side, with reduction of ∼10-15% in weight

Fifteen Eya1/Six1 129 compound heterozygotes showed small kidneys either bilaterally (n=9) or unilaterally (n=6), with reduction of ∼75-22% in weight

§

One Eya1+/- C57BL6 animal showed smaller kidney on one side, with reduction of ∼15% in weight

Ten Eya1/Six1 C57BL6 compound heterozygotes showed small kidneys either unilaterally (n=6) or bilaterally (n=4). Weight reduction was from 20 to 30%, less severe than that observed in 129 background

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