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Table 4.

Wnt11 and Ret mutations synergistically interact to yield kidney hypoplasia

GenotypeNumber of glomeruli (±s.d.)n
Ret+/+; Wnt11+/+ 1358±258 
Ret+/-; Wnt11+/+ 1447±278 
Ret+/+; Wnt11-/- 1055±161 
Ret+/-; Wnt11+/- 702±40 
Ret+/-; Wnt11-/- 469±131 10 
GenotypeNumber of glomeruli (±s.d.)n
Ret+/+; Wnt11+/+ 1358±258 
Ret+/-; Wnt11+/+ 1447±278 
Ret+/+; Wnt11-/- 1055±161 
Ret+/-; Wnt11+/- 702±40 
Ret+/-; Wnt11-/- 469±131 10 

Average total numbers of glomeruli in E18.5 kidneys from Ret;Wnt11double mutant combinations are shown. Ret+/-;Wnt11+/- kidneys contain fewer glomeruli than wild-type controls. Ret+/-;Wnt11-/- kidneys are much smaller than either Ret+/- or Wnt11-/-kidneys by themselves. Ret+/- kidneys are not statistically significantly different in size from genotypically wild-type controls. Glomeruli were counted from 6 μm coronal Hematoxylin/Eosin stained kidney sections.

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